Identification of hepatic progenitor cells in the canine fetal liver

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorTavares, M. R. [UNESP]-
Autor(es): dc.creatorCastro, R. V. G. de [UNESP]-
Autor(es): dc.creatorPieri, N. C. G.-
Autor(es): dc.creatorCruz, N. R. N. [UNESP]-
Autor(es): dc.creatorMartins, D. S.-
Autor(es): dc.creatorAmbrosio, C. E.-
Autor(es): dc.creatorGarcia, J. M. [UNESP]-
Autor(es): dc.creatorCamplesi, A. C. [UNESP]-
Autor(es): dc.creatorBressan, F. F.-
Autor(es): dc.creatorToniollo, G. H. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:57:41Z-
Data de disponibilização: dc.date.available2022-02-22T00:57:41Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.rvsc.2020.09.012-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/209806-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/209806-
Descrição: dc.descriptionThe liver plays essential roles in human and animal organisms, such as the storage, release, metabolism, and elimination of various endogenous or exogenous substances. Although its vital importance, few treatments are yet available when a hepatic failure occurs, and hence, the use of stem cells has arisen as a possible solution for both human and veterinary medicines. Previous studies have shown the existence of hepatic progenitor cells in human fetuses that were positive for EpCAM and NCAM. There is limited evidence, however, further identification and characterization of these cells in other species. Considering the similarity between dogs and humans regarding physiology, and also the increasing importance of developing new treatments for both veterinary and translational medicine, this study attempted to identify hepatic progenitor cells in canine fetal liver. For that, livers from canine fetuses were collected, cells were isolated by enzymatic digestion and cultured. Cells were characterized regarding morphology and expression of EpCAM, NCAM, Nestin, and Thy-1/CD90 markers. Our results suggest that it is possible to identify hepatic progenitor cells in the canine fetal liver; however, for therapeutic use, further techniques for cellular isolation and culture are necessary to obtain enriched populations of hepatic progenitors from the canine fetal liver.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionState Univ Sao Paulo, Fac Agr & Anim Sci, Dept Prevent Vet Med & Anim Reprod, Jaboticabal, SP, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Fac Anim Sci & Food Engn, Dept Vet Med, Pirassununga, SP, Brazil-
Descrição: dc.descriptionState Univ Sao Paulo, Fac Agr & Anim Sci, Dept Vet Clin & Surg, Jaboticabal, SP, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Fac Vet Med & Anim Sci, Postgrad Program Anat Domest & Wild Anim, Sao Paulo, SP, Brazil-
Descrição: dc.descriptionState Univ Sao Paulo, Fac Agr & Anim Sci, Dept Prevent Vet Med & Anim Reprod, Jaboticabal, SP, Brazil-
Descrição: dc.descriptionState Univ Sao Paulo, Fac Agr & Anim Sci, Dept Vet Clin & Surg, Jaboticabal, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2017/21266-0-
Formato: dc.format239-245-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationResearch In Veterinary Science-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectLiver-
Palavras-chave: dc.subjectEpCAM-
Palavras-chave: dc.subjectNCAM-
Palavras-chave: dc.subjectDog-
Palavras-chave: dc.subjectStem cells-
Título: dc.titleIdentification of hepatic progenitor cells in the canine fetal liver-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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