Electrodeposition of bactericidal and bioactive nano-hydroxyapatite onto electrospun piezoelectric polyvinylidene fluoride scaffolds

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUFPI Fed Univ Piaui-
Autor(es): dc.contributorUniv Brasil-
Autor(es): dc.contributorUniv UniMetrocamp-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniv Santo Amaro-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorRodrigues, Pedro J. G.-
Autor(es): dc.creatorElias, Conceicao de M. V.-
Autor(es): dc.creatorViana, Bartolomeu C.-
Autor(es): dc.creatorHollanda, Luciana M. de-
Autor(es): dc.creatorStocco, Thiago D.-
Autor(es): dc.creatorVasconcellos, Luana M. R. de [UNESP]-
Autor(es): dc.creatorMello, Daphne de C. R. [UNESP]-
Autor(es): dc.creatorSantos, Francisco E. P.-
Autor(es): dc.creatorMarciano, Fernanda R.-
Autor(es): dc.creatorLobo, Anderson O.-
Data de aceite: dc.date.accessioned2022-02-22T00:57:34Z-
Data de disponibilização: dc.date.available2022-02-22T00:57:34Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-13-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1557/jmr.2020.302-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/209771-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/209771-
Descrição: dc.descriptionThe fibrous scaffolds for bone tissue engineering that mimic the extracellular matrix with bioactive and bactericidal properties could provide adequate conditions for regeneration of damaged bone. Electrospun ultrathin fiber covered with nano-hydroxyapatite is a favorable fibrous scaffold design. We developed a fast and reproducible strategy to produce polyvinylidene fluoride (PVDF)/nano-hydroxyapatite (nHAp) nanofibrous scaffolds with bactericidal and bioactive properties. Fibrous PVDF scaffolds were obtained first by the electrospinning method. Then, their surfaces were modified using oxygen plasma treatment followed by electrodeposition of nHAp. This process formed nanofibrous and superhydrophilic PVDF fibers (133.6 nm, fiber average diameter) covered with homogeneous nHAp (202.6 nm, average particle diameter) crystals. Energy-dispersive X-ray spectrometry demonstrated the presence of calcium phosphate, indicating a Ca/P molar ratio of approximately 1.64. X-ray diffraction, Fourier transform infrared spectroscopy, and Raman spectroscopy spectra identified beta-phase of nHAp. Thermal analysis indicated a slight reduction in stability after nHAp electrodeposition. Bactericidal assays showed that nHAp exhibited 99.8% efficiency against Pseudomonas aeruginosa bacteria. The PVDF/Plasma and PVDF/nHAp groups had the highest cell viability, total protein, and alkaline phosphatase activity by 7 days after exposure of the scaffolds to MG63 cell culture. Therefore, the developed scaffolds are an exciting alternative for application in bone regeneration.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionUFPI Fed Univ Piaui, Mat Sci & Engn Grad Program, BioMatLab Grp, LIMAV Interdisciplinary Lab Adv Mat, BR-64049550 Teresina, Piaui, Brazil-
Descrição: dc.descriptionUniv Brasil, Inst Cient & Tecnol, BR-08230030 Sao Paulo, Brazil-
Descrição: dc.descriptionUFPI Fed Univ Piaui, Dept Phys, 64049550 Teresina, PI, Brazil-
Descrição: dc.descriptionUniv UniMetrocamp, BR-13035500 Campinas, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Campinas, Fac Med Sci, BR-13083970 Campinas, SP, Brazil-
Descrição: dc.descriptionUniv Santo Amaro, BR-04829300 Sao Paulo, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Inst Sci & Technol, Dept Biosci & Oral Diag, BR-12247004 Sao Jose Dos Campos, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Inst Sci & Technol, Dept Biosci & Oral Diag, BR-12247004 Sao Jose Dos Campos, SP, Brazil-
Descrição: dc.descriptionCNPq: 303752/2017-3-
Descrição: dc.descriptionCNPq: 404683/2018-5-
Descrição: dc.descriptionCNPq: 304133/2017-5-
Descrição: dc.descriptionCNPq: 424163/2016-0-
Formato: dc.format3265-3275-
Idioma: dc.languageen-
Publicador: dc.publisherCambridge Univ Press-
Relação: dc.relationJournal Of Materials Research-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectpolyvinylidene fluoride-
Palavras-chave: dc.subjectnano-hydroxyapatite-
Palavras-chave: dc.subjectnanotechnology-
Palavras-chave: dc.subjectelectrospinning-
Palavras-chave: dc.subjectelectrodeposition-
Palavras-chave: dc.subjectbactericidal-
Palavras-chave: dc.subjectbone regeneration-
Título: dc.titleElectrodeposition of bactericidal and bioactive nano-hydroxyapatite onto electrospun piezoelectric polyvinylidene fluoride scaffolds-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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