Higher Concentration of Taenia Antigens in the CSF is Related to Slight Ventricle Enlargement and Periventricular Neuronal Decrease in Young Rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorSilva, Monica Almeida [UNESP]-
Autor(es): dc.creatorBarcelos, Eduardo Vieira [UNESP]-
Autor(es): dc.creatorAves Junior, Aderaldo Costa [UNESP]-
Autor(es): dc.creatorGeneroso, Diego [UNESP]-
Autor(es): dc.creatorAlda, Maiara Almeida-
Autor(es): dc.creatorBatah, Sabrina Setembre-
Autor(es): dc.creatorFabro, Alexandre Todorovic-
Autor(es): dc.creatorMachado, Vania Maria de Vasconcelos [UNESP]-
Autor(es): dc.creatorHamamoto Filho, Pedro Tadao [UNESP]-
Autor(es): dc.creatorZanini, Marco Antonio [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:57:22Z-
Data de disponibilização: dc.date.available2022-02-22T00:57:22Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-11-25-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1055/s-0040-1718997-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/209688-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/209688-
Descrição: dc.descriptionPurpose Experimental models might help understand the pathophysiology of neurocysticercosis-associated hydrocephalus. The present study aimed to compare the extent of hydrocephalus and tissue damage in rats with subarachnoid inoculation of different concentrations of Taenia crassiceps cyst proteins. Methods Sixty young rats were divided into two groups: low- and high-concentration groups. The animals in the low concentration group received 0.02ml of 2.4mg/ml T. crassiceps cyst proteins while those in the high concentration group received 0.02 ml of 11.6mg/ml T. crassiceps cyst proteins. The animals underwent magnetic resonance imaging at 1, 3, and 6 months postinoculation to assess the ventricle volume. Morphological assessment was performed at the end of the observation period. Results Repeated measures of ventricle volumes at 1, 3, and 6 months showed progressive enlargement of the ventricles. At 1 and 3 months, we observed no differences in ventricle volumes between the 2 groups. However, at 6 months, the ventricles were larger in the high concentration group (median = 3.86mm(3), range: 2.37-12.68) compared with the low concentration group (median = 2.00mm(3), range: 0.37- 11.57), p = 0.003. The morphological assessment revealed a few inflammatory features in both groups. However, the density of oligodendrocytes and neurons within the periventricular region was lower in the high concentration group (5.18 versus 9.72 for oligodendrocytes and 15.69 versus 21.00 for neurons; p < 0.001 for both). Conclusion Our results suggest that, in rats, a higher concentration of T. crassiceps cyst proteins in the subarachnoid space could induce ventricle enlargement and reduce the number of neurons within the periventricular area.-
Descrição: dc.descriptionUniv Estadual Paulista, Botucatu Med Sch, Dept Neurol Psychol & Psychiat, Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Ribeirao Preto Med Sch, Dept Pathol & Legal Med, Ribeirao Preto, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Sch Vet Med & Anim Sci, Dept Anim Reprod & Vet Radiol, Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Botucatu Med Sch, Dept Neurol Psychol & Psychiat, Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Sch Vet Med & Anim Sci, Dept Anim Reprod & Vet Radiol, Botucatu, SP, Brazil-
Formato: dc.format6-
Idioma: dc.languageen-
Publicador: dc.publisherGeorg Thieme Verlag Kg-
Relação: dc.relationBrazilian Neurosurgery-arquivos Brasileiros De Neurocirurgia-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectneurocysticercosis-
Palavras-chave: dc.subjecthydrocephalus-
Palavras-chave: dc.subjectneurons-
Palavras-chave: dc.subjectexperimental model-
Título: dc.titleHigher Concentration of Taenia Antigens in the CSF is Related to Slight Ventricle Enlargement and Periventricular Neuronal Decrease in Young Rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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