Clinical, Epidemiological, and Geospatial Characteristics of Patients Infected with Hepatitis C Virus Treated with Second-Generation Direct-Action Antivirals in a Reference Center in a Mesoregion of Sao Paulo State, Brazil

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorOeste Paulista Univ-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorPharm Outpatient Med Specialties Presidente Prude-
Autor(es): dc.creatorPena, Danilo Zangirolami-
Autor(es): dc.creatorAnadao, Murilo Fernandes-
Autor(es): dc.creatorFlores, Edilson Ferreira [UNESP]-
Autor(es): dc.creatorOkada, Mayara Namimatsu-
Autor(es): dc.creatorFilho, Alexandre Martins Portelinha-
Autor(es): dc.creatorFerro, Rodrigo Sala-
Autor(es): dc.creatorPrestes-Carneiro, Luiz Euribel-
Data de aceite: dc.date.accessioned2022-02-22T00:57:09Z-
Data de disponibilização: dc.date.available2022-02-22T00:57:09Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/microorganisms8101575-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/209630-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/209630-
Descrição: dc.descriptionHepatitis virus infection is a major public health problem worldwide. Currently, Brazil has almost 700,000 cases. The Brazilian Unified Health System (SUS) provides therapeutic regimens for people infected with hepatitis C virus (HCV). We determined the clinical, laboratory, epidemiologic, and geospatial characteristics of patients infected with HCV treated with second-generation direct-action antivirals (DAAs) in a hospital reference center in Sao Paulo state, Brazil, using data from file records. A map was constructed using a geographic information system. From 2015 to 2018, 197 individuals received second-generation DAAs (mean age, 57.68 +/- 1.36 years; interquartile range, 56.22-59.14 years; 58.9% male; 41.1% female). Genotypes 1a and 1b accounted for 75.7% of cases and the prevalent therapeutic regimen was sofosbuvir/simeprevir. Sustained viral response accounted for 98.9% and the METAVIR score F3/F4 for 50.8%. Increased alanine transferase was significantly correlated with an increase in alpha-fetoproteins (p = 0.01), and severe necro-inflammatory activity (p = 0.001). Associated comorbidities were found in 71.6%, mainly coronary artery and gastrointestinal disorders. The cumulative incidence in the region was 2.6 per 10,000 inhabitants. Our data highlight the role of reference hospitals in Brazil's public health system in the treatment of HCV. Low incidence rates demonstrated the fragility of municipalities in the active search for patients.-
Descrição: dc.descriptionOeste Paulista Univ, Infect Dis Outpatient Clin, BR-19050920 Presidente Prudente, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Stat Dept, Sch Sci & Technol, BR-19060900 Presidente Prudente, SP, Brazil-
Descrição: dc.descriptionPharm Outpatient Med Specialties Presidente Prude, BR-19050680 Presidente Prudente, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Stat Dept, Sch Sci & Technol, BR-19060900 Presidente Prudente, SP, Brazil-
Formato: dc.format13-
Idioma: dc.languageen-
Publicador: dc.publisherMdpi-
Relação: dc.relationMicroorganisms-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectsustained virological response-
Palavras-chave: dc.subjectcomorbidities-
Palavras-chave: dc.subjectgastrointestinal-
Palavras-chave: dc.subjectdepression-
Palavras-chave: dc.subjectincidence-
Título: dc.titleClinical, Epidemiological, and Geospatial Characteristics of Patients Infected with Hepatitis C Virus Treated with Second-Generation Direct-Action Antivirals in a Reference Center in a Mesoregion of Sao Paulo State, Brazil-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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