Immunological and bacteriological shifts associated with a flagellin-hyperproducing Salmonella Enteritidis mutant in chickens

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorUniversidade Federal da Paraíba (UFPB)-
Autor(es): dc.contributorUniv Copenhagen-
Autor(es): dc.creatorBarbosa, Fernanda de Oliveira [UNESP]-
Autor(es): dc.creatorFreitas Neto, Oliveiro Caetano de-
Autor(es): dc.creatorRodrigues Alves, Lucas Bocchini [UNESP]-
Autor(es): dc.creatorBenevides, Valdinete Pereira [UNESP]-
Autor(es): dc.creatorSecundo de Souza, Andrei Itajahy [UNESP]-
Autor(es): dc.creatorRubio, Marcela da Silva [UNESP]-
Autor(es): dc.creatorAlmeida, Adriana Maria de [UNESP]-
Autor(es): dc.creatorSaraiva, Mauro Mesquita [UNESP]-
Autor(es): dc.creatorBruno de Oliveira, Celso Jose-
Autor(es): dc.creatorOlsen, John Elmerdahl-
Autor(es): dc.creatorBerchieri Junior, Angelo [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:57:07Z-
Data de disponibilização: dc.date.available2022-02-22T00:57:07Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-11-03-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s42770-020-00399-7-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/209618-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/209618-
Descrição: dc.descriptionSalmonella Enteritidis causes infections in humans and animals which are often associated with extensive gut colonization and bacterial shedding in faeces. The natural presence of flagella in Salmonella enterica has been shown to be enough to induce pro-inflammatory responses in the gut, resulting in recruitment of polymorphonuclear cells, gut inflammation and, consequently, reducing the severity of systemic infection in chickens. On the other hand, the absence of flagellin in some Salmonella strains favours systemic infection as a result of the poor intestinal inflammatory responses elicited. The hypothesis that higher production of flagellin by certain Salmonella enterica strains could lead to an even more immunogenic and less pathogenic strain for chickens was here investigated. In the present study, a Salmonella Enteritidis mutant strain harbouring deletions in clpP and fliD genes (SE Delta clpPfliD), which lead to overexpression of flagellin, was generated, and its immunogenicity and pathogenicity were comparatively assessed to the wild type in chickens. Our results showed that SE Delta clpPfliD elicited more intense immune responses in the gut during early stages of infection than the wild type did, and that this correlated with earlier intestinal and systemic clearance of the bacterium.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionState Univ Sao Paulo, Sch Agr & Veterinarian Sci FCAV, Dept Vet Pathol, Jaboticabal, Brazil-
Descrição: dc.descriptionFed Univ Minas Gerais UFMG, Vet Sch, Dept Prevent Vet Med, Av Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil-
Descrição: dc.descriptionFed Univ Paraiba CCA UFPB, Ctr Agr Sci, Dept Anim Sci, Areia, PB, Brazil-
Descrição: dc.descriptionUniv Copenhagen, Dept Vet & Anim Sci, Stigbojlen 4, DK-1870 Frederiksberg C, Denmark-
Descrição: dc.descriptionState Univ Sao Paulo, Sch Agr & Veterinarian Sci FCAV, Dept Vet Pathol, Jaboticabal, Brazil-
Descrição: dc.descriptionFAPESP: 2018/04883-8-
Descrição: dc.descriptionFAPESP: 2016/10369-0-
Formato: dc.format419-429-
Idioma: dc.languageen-
Publicador: dc.publisherSpringer-
Relação: dc.relationBrazilian Journal Of Microbiology-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectFlagellin-
Palavras-chave: dc.subjectPoultry-
Palavras-chave: dc.subjectSalmonellosis-
Palavras-chave: dc.subjectMutant-
Palavras-chave: dc.subjectDeletion-
Título: dc.titleImmunological and bacteriological shifts associated with a flagellin-hyperproducing Salmonella Enteritidis mutant in chickens-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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