Expression of AIF, PARP, and miRNAs MIR-145, MIR-210, and MIR-486 Associated with Apoptosis in the Corpus Cavernosum of Rats Subjected to Chronic Alcoholism Model

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniv Ribeirao Preto-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorUniv Marilia-
Autor(es): dc.creatorSarraipo, Vagner Schiavoni-
Autor(es): dc.creatorLizarte Neto, Fermino Sanches-
Autor(es): dc.creatorMello de Carvalho, Camila Albuquerque-
Autor(es): dc.creatorSilva, Jairo Pinheiro da-
Autor(es): dc.creatorDurand, Marina Toledo-
Autor(es): dc.creatorSchimming, Bruno Cezar [UNESP]-
Autor(es): dc.creatorMartinez, Marcelo-
Autor(es): dc.creatorTazima Sorita Galli, Maria de Fatima-
Autor(es): dc.creatorBuono, Fabianna de Oliveira-
Autor(es): dc.creatorBarbirato da Mata Tiezzi, Maria Fernanda-
Autor(es): dc.creatorNovais, Paulo Cezar-
Autor(es): dc.creatorGula, Isabella Stracieri-
Autor(es): dc.creatorThomazini, Jose Antonio-
Autor(es): dc.creatorSassoli Fazan, Valeria Paula-
Autor(es): dc.creatorRodrigues, Andressa Romualdo-
Autor(es): dc.creatorCunha Tirapelli, Daniela Pretti da-
Autor(es): dc.creatorAssis Cirino, Mucio Luiz de-
Autor(es): dc.creatorFernandes Molina, Carlos Augusto-
Autor(es): dc.creatorTucci Junior, Silvio-
Autor(es): dc.creatorTirapelli, Luis Fernando-
Data de aceite: dc.date.accessioned2022-02-22T00:57:07Z-
Data de disponibilização: dc.date.available2022-02-22T00:57:07Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-11-30-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/209617-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/209617-
Descrição: dc.descriptionPrevious studies from our group described the consequences of using ethanol on penile erection. Nevertheless, the molecular mechanisms surrounding microRNAs, apoptosis process and their relationship with erectile dysfunction associated with alcohol consumption are still poorly understood. The objective of this analysis was to evaluate the mechanism of apoptosis by the expression of AIF and PARP, as well as their regulatory microRNAs: miR-145, miR-210 and miR-486, in the corpus cavemosum of rats submitted to a semivoltmtary alcoholism model. For this study 24 Wistar rats were divided into two groups: control (C) and treated with 20 % ethanol (A) for seven weeks. The corpus cavernosum samples were prepared for immunohistochemical analysis of AIF and PARP protein expression, and microRNAs miR-145, miR-210, miR-486 gene expression in cavernous tissue was performed by real time PCR. The immunohistochemical analysis showed little nuclear positive labeling for the protein PARP and AIF in the corpus cavernosum of control and ethanol treated animals. After analysis of miR-145, -210 and -486 microRNA expression in the 12 animals studied, no results were found with significant statistical difference between the control and alcoholized groups. The expression ofAIF and PARP and their regulatory inicroRNAs involved in apoptotic process (miR-145, miR-210 and miR-486) were not altered in the corpus cavernosum of rats submitted to semivoltmtary alcoholism.-
Descrição: dc.descriptionSao Paulo Univ USP, Med Sch Ribeirao Preto, Dept Surg & Anat, Ribeirao Preto, SP, Brazil-
Descrição: dc.descriptionUniv Ribeirao Preto, Dept Med, Ribeirao Preto, Brazil-
Descrição: dc.descriptionUNESP, Biosci Inst Botucatu, Dept Anat, Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Fed Sao Carlos, Dept Morphol & Pathol, Sao Carlos, SP, Brazil-
Descrição: dc.descriptionUniv Marilia, Dept Odontol, Marilia, SP, Brazil-
Descrição: dc.descriptionUniv Marilia, Postgrad Program Struct & Funct Interact Rehabil, Marilia, SP, Brazil-
Descrição: dc.descriptionUNESP, Biosci Inst Botucatu, Dept Anat, Botucatu, SP, Brazil-
Formato: dc.format1639-1644-
Idioma: dc.languageen-
Publicador: dc.publisherSoc Chilena Anatomia-
Relação: dc.relationInternational Journal Of Morphology-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectAlcoholism-
Palavras-chave: dc.subjectApoptosis-
Palavras-chave: dc.subjectErectile Dysfunction-
Palavras-chave: dc.subjectMicroRNAs-
Título: dc.titleExpression of AIF, PARP, and miRNAs MIR-145, MIR-210, and MIR-486 Associated with Apoptosis in the Corpus Cavernosum of Rats Subjected to Chronic Alcoholism Model-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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