Physical exercise protocols in animal models of Alzheimer's disease: a systematic review

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFed Univ Valleys Jequitinhonha & Mucuri-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal da Bahia (UFBA)-
Autor(es): dc.creatorDe Sousa, Ricardo Augusto Leoni-
Autor(es): dc.creatorRodrigues, Cintia Maria [UNESP]-
Autor(es): dc.creatorMendes, Bruno Ferreira-
Autor(es): dc.creatorImprota-Caria, Alex Cleber-
Autor(es): dc.creatorPeixoto, Marco Fabricio Dias-
Autor(es): dc.creatorCassilhas, Ricardo Cardoso-
Data de aceite: dc.date.accessioned2022-02-22T00:57:02Z-
Data de disponibilização: dc.date.available2022-02-22T00:57:02Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-10-22-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s11011-020-00633-z-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/209586-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/209586-
Descrição: dc.descriptionSeveral animal studies have showed the beneficial effects of physical exercise (PE) on brain function and health. Alzheimer's Disease (AD) is the most common type of dementia, characterized by the presence of aggregated extracellular amyloid-beta (A beta) and neurofibrillary tangles, with progressive cognitive decline. Therapeutic approaches such as PE showed to be effective in halting AD progression. Here, we present a systematic review about PE and AD. The search was carried out using the PubMed and LILACS databases. The following keywords were used: Alzheimer; PE; animal model. All found studies adopted aerobic exercise training as the PE protocol (100%). We identified running on treadmill as the most commonly used PE routine (62.5%). The duration of each session, intensity, frequency, and period of training most used were 60 min/day (62.5%), moderate intensity (87.5%), 5 days/week (62.5%), and 4 (37.5%) or 12 (37.5%) weeks, respectively. The AD animal models most used were the Tg APP/PS1 Delta E9 (25%), models based on i.c.v. infusion of A beta Os (25%) and streptozotocin (25%). All protocols used rodents to their experiments (100%), but mice were the most common (62.5%). Finally, the main results presented in all studies were capable to reduce significantly AD consequences, such as reducing A beta or pro-inflammatory proteins levels (100%). The lack of resistance training protocols in animal models of AD indicates a huge gap that should be investigated in future studies. We suggest that PE protocols must be adapted according to the specie, lineage and life span of the animal.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFed Univ Valleys Jequitinhonha & Mucuri, Multictr Post Grad Program Physiol Sci, Brazilian Soc Physiol, Diamantina, MG, Brazil-
Descrição: dc.descriptionFed Univ Valleys Jequitinhonha & Mucuri, Neurosci & Exercise Study Grp, Diamantina, MG, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Fudamental Nursing Post Grad Program, Ribeirao Preto, SP, Brazil-
Descrição: dc.descriptionUniv Fed Bahia, Postgrad Program Med & Hlth, Salvador, BA, Brazil-
Descrição: dc.descriptionFed Univ Valleys Jequitinhonha & Mucuri, Postgrad Program Hlth Sci, Diamantina, MG, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Fudamental Nursing Post Grad Program, Ribeirao Preto, SP, Brazil-
Descrição: dc.descriptionCAPES: 001-
Formato: dc.format85-95-
Idioma: dc.languageen-
Publicador: dc.publisherSpringer-
Relação: dc.relationMetabolic Brain Disease-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectPhysical activity-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectCognitive decline-
Palavras-chave: dc.subjectMemory-
Palavras-chave: dc.subjectDementia-
Título: dc.titlePhysical exercise protocols in animal models of Alzheimer's disease: a systematic review-
Aparece nas coleções:Repositório Institucional - Unesp

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