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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Univ Fed Rio Grande do Norte | - |
Autor(es): dc.contributor | Inst Tecnol Alimentos ITAL | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Univ Fed Parana | - |
Autor(es): dc.creator | Silva Viana, Rony Lucas | - |
Autor(es): dc.creator | Pereira Fidelis, Gabriel | - |
Autor(es): dc.creator | Jane Campos Medeiros, Mayara | - |
Autor(es): dc.creator | Antonio Morgano, Marcelo | - |
Autor(es): dc.creator | Gabriela Chagas Faustino Alves, Monique | - |
Autor(es): dc.creator | Domingues Passero, Luiz Felipe [UNESP] | - |
Autor(es): dc.creator | Lima Pontes, Daniel | - |
Autor(es): dc.creator | Cordeiro Theodoro, Raquel | - |
Autor(es): dc.creator | Domingos Arantes, Thales | - |
Autor(es): dc.creator | Araujo Sabry, Diego | - |
Autor(es): dc.creator | Lanzi Sassaki, Guilherme | - |
Autor(es): dc.creator | Fagundes Melo-Silveira, Raniere | - |
Autor(es): dc.creator | Rocha, Hugo Alexandre Oliveira | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:57:01Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:57:01Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2020-09-01 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.3390/biom10091235 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/209581 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/209581 | - |
Descrição: dc.description | Corn cob is an agricultural byproduct that produces an estimated waste burden in the thousands of tons annually, but it is also a good source of xylan, an important bioactive polysaccharide. Silver nanoparticles containing xylan (nanoxylan) were produced using an environmentally friendly synthesis method. To do this, we extracted xylan from corn cobs using an ultrasound technique, which was confirmed by both chemical and NMR analyses. This xylan contained xylose, glucose, arabinose, galactose, mannose, and glucuronic acid in a molar ratio of 50:21:14:9:2.5:2.5, respectively. Nanoxylan synthesis was analyzed using UV-vis spectroscopy at kmax = 469 nm and Fourier transform infrared spectroscopy (FT-IR), which confirmed the presence of both silver and xylan in the nanoxylan product. Dynamic light scattering (DLS) and atomic force microscopy (AFM) revealed that the nanoxylan particles were similar to 102.0 nm in size and spherical in shape, respectively. DLS also demonstrated that nanoxylan was stable for 12 months and coupled plasma optical emission spectrometry (ICP-OES) showed that the nanoxylan particles were 19% silver. Nanoxylan reduced Leishmania amazonensis promastigote viability with a half maximal inhibitory concentration (IC50) value of 25 mu g/mL, while xylan alone showed no effective. Additionally, nanoxylan exhibited antifungal activity against Candida albicans (MIC = 7.5 mu g/mL), C. parapsilosis (MIC = 7.5 mu g/mL), and Cryptococcus neoformans (MIC = 7.5 mu g/mL). Taken together, these data suggest that it is possible to synthesize silver nanoparticles using xylan and that these nanoxylan exert improved antileishmanial and antifungal activities when compared to the untreated polysaccharide or silver nitrate used for their synthesis. Thus, nanoxylan may represent a promising new class of antiparasitic agents for use in the treatment of these microorganisms. | - |
Descrição: dc.description | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
Descrição: dc.description | Univ Fed Rio Grande do Norte, Dept Bioquim, BR-59078970 Natal, RN, Brazil | - |
Descrição: dc.description | Univ Fed Rio Grande do Norte, Dept Quim, BR-59078970 Natal, RN, Brazil | - |
Descrição: dc.description | Inst Tecnol Alimentos ITAL, Ctr Ciencias & Qualidade Alimentos CCQA, BR-13070178 Campinas, SP, Brazil | - |
Descrição: dc.description | Univ Estadual Sao Paulo Unesp, Inst Biociencias, Praca Infante Dom Henrique S-N, BR-11330900 Sao Vicente, SP, Brazil | - |
Descrição: dc.description | Univ Fed Parana, Dept Bioquim, BR-80060000 Curitiba, PR, Brazil | - |
Descrição: dc.description | Univ Estadual Sao Paulo Unesp, Inst Biociencias, Praca Infante Dom Henrique S-N, BR-11330900 Sao Vicente, SP, Brazil | - |
Descrição: dc.description | CNPq: nffi 485813/2012-2 | - |
Formato: dc.format | 21 | - |
Idioma: dc.language | en | - |
Publicador: dc.publisher | Mdpi | - |
Relação: dc.relation | Biomolecules | - |
???dc.source???: dc.source | Web of Science | - |
Palavras-chave: dc.subject | polysaccharides | - |
Palavras-chave: dc.subject | antiparasitic | - |
Palavras-chave: dc.subject | agricultural byproduct | - |
Palavras-chave: dc.subject | nanomaterials | - |
Título: dc.title | Green Synthesis of Antileishmanial and Antifungal Silver Nanoparticles Using Corn Cob Xylan as a Reducing and Stabilizing Agent | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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