Subgingival endotoxin and lipoteichoic acid modulate cytokine production in diabetic subjects: A Case-control Study

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Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorRangel, Thiago P.-
Autor(es): dc.creatorReis, Aurelio A.-
Autor(es): dc.creatorCaponi, Lara-
Autor(es): dc.creatorPena, Larissa C. S.-
Autor(es): dc.creatorRuiz, Karina G. S.-
Autor(es): dc.creatorSantamaria, Mauro P. [UNESP]-
Autor(es): dc.creatorMathias-Santamaria, Ingrid F. [UNESP]-
Autor(es): dc.creatorCasati, Marcio Z.-
Autor(es): dc.creatorCasarin, Renato C. V.-
Data de aceite: dc.date.accessioned2022-02-22T00:57:00Z-
Data de disponibilização: dc.date.available2022-02-22T00:57:00Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-10-22-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/odi.13661-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/209577-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/209577-
Descrição: dc.descriptionBackground Periodontal disease and diabetes mellitus (DM) are highly prevalent and interrelated diseases, resulting in altered host response microbiota. Thus, this study aimed to evaluate the impact of DM on local levels of lipopolysaccharide (LPS) and lipoteichoic acid (LTA) and their relationship with cytokines and matrix metalloproteinases' (MMPs) profile. Methods This case-control study included diabetic (n = 15) and non-diabetic (n = 15) subjects presenting Stage 3-4, Grade C, Periodontitis. Gingival crevicular fluid (GCF) was collected, and LPS and LTA levels were analyzed by enzyme-linked immunosorbent assay (ELISA), while IFN-gamma, IL-10, IL-17, IL-1 beta, IL-4, MMP-2, and MMP-9 were measured by LUMINEX/MAGpix. Mann-Whitney and Spearman's correlation tests were used to compared and to correlate variables (p < 0.05). Results Higher levels of LTA, LPS, IL-10, IL-1 beta, and MMP-2 (p < 0.05) and lower levels of IL-17 were found in the DM group (p < 0.05). Non-diabetic subjects presented higher LPS, IFN-gamma, IL-17, and MMP-2 levels and lower IL-10 concentration (p < 0.05). No significant correlation was seen between LPS and cytokine profile in non-diabetic. Local levels of LTA were positively correlated with IL-17 and MMP-2 and negatively with IL-10. Conclusion LTA and LPS drove the inflammatory profile through the modulation of cytokines and MMPs in a different manner in DM and non-diabetic subjects.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionUniv Estadual Campinas, Dent Sch Piracicaba, Dept Prosthodont & Periodont, Campinas, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Div Periodontol, Coll Dent, FOSJC, Sao Paulo, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Div Periodontol, Coll Dent, FOSJC, Sao Paulo, Brazil-
Descrição: dc.descriptionFAPESP: 2015/502640-
Descrição: dc.descriptionFAPESP: 2018/12208-9-
Descrição: dc.descriptionCAPES: 001-
Formato: dc.format9-
Idioma: dc.languageen-
Publicador: dc.publisherWiley-Blackwell-
Relação: dc.relationOral Diseases-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectcytokines-
Palavras-chave: dc.subjectdiabetes mellitus-
Palavras-chave: dc.subjectperiodontitis-
Palavras-chave: dc.subjectvirulence factors-
Título: dc.titleSubgingival endotoxin and lipoteichoic acid modulate cytokine production in diabetic subjects: A Case-control Study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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