Antimicrobial Therapeutics in Regenerative Endodontics: A Scoping Review

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Autor(es): dc.contributorUniv Michigan-
Autor(es): dc.contributorUniv Fed Pelotas-
Autor(es): dc.contributorUniv Fed Rio Grande do Sul-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorRibeiro, Juliana S.-
Autor(es): dc.creatorMiinchow, Eliseu A.-
Autor(es): dc.creatorBordini, Ester A. Ferreira [UNESP]-
Autor(es): dc.creatorOliveira da Rosa, Wellington Luiz de-
Autor(es): dc.creatorBottino, Marco C.-
Data de aceite: dc.date.accessioned2022-02-22T00:56:44Z-
Data de disponibilização: dc.date.available2022-02-22T00:56:44Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.joen.2020.06.032-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/209491-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/209491-
Descrição: dc.descriptionIntroduction: This review aimed to provide a critical appraisal of alternative antimicrobial strategies in lieu of traditional triple antibiotic paste (TAP). Methods: This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The literature search was performed in 8 databases (PubMed/Medline, Embase, LILACS, Web of Science, Scopus, BVS, SciELO, and the Cochrane Library), selecting clinical, in vitro, in vivo, and in situ studies that evaluated antimicrobial alternatives to TAP in regenerative endodontics. Studies lacking an experimental TAP group were excluded. Results: A total of 1705 potentially relevant records were initially identified. From the 38 studies retrieved for full-text reading, 16 fulfilled all selection criteria and were included in the qualitative analysis. According to the study design, 11 studies were solely in vitro, 1 study was both in vitro and in vivo (animal model), 2 studies were solely animal experiments, and 2 studies were clinical trials. The alternative antimicrobial agents to TAP consisted of modified TAP formulations (eg, a combination of TAP with chitosan); TAP-eluting nanofibers; propolis; chlorhexidine (CHX) gels/solutions; double antibiotic pastes composed of distinct combinations of antibiotics; Ca(OH)2-based formulations; and sodium hypochlorite. Overall, most of the alternative agents performed similarly to TAP, although some strategies (eg, Ca(OH)2- and CHX-based formulations) seemed to present dubious importance in the control of infection. Conclusions: TAP still remains an excellent option in terms of the complete elimination of microorganisms. This review points to the use of electrospun fibers as a drug delivery system to offer a controlled release of the antimicrobial agent, as well as the use of natural compounds, deserving future investigation.-
Descrição: dc.descriptionNational Institutes of Health (NIH)/National Institute of Dental and Craniofacial Research (NIDCR)-
Descrição: dc.descriptionUniv Michigan, Sch Dent, Dept Cariol Restorat Sci & Endodont, 1011 North Univ Ave,Room 5223, Ann Arbor, MI 48109 USA-
Descrição: dc.descriptionUniv Fed Pelotas, Sch Dent, Grad Program Dent, Pelotas, RS, Brazil-
Descrição: dc.descriptionUniv Fed Rio Grande do Sul, Sch Dent, Dept Conservat Dent, Porto Alegre, RS, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Araraquara Sch Dent, Dept Dent Mat & Prosthodont, Araraquara, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Araraquara Sch Dent, Dept Dent Mat & Prosthodont, Araraquara, SP, Brazil-
Descrição: dc.descriptionNational Institutes of Health (NIH)/National Institute of Dental and Craniofacial Research (NIDCR): R01DE026578-
Formato: dc.formatS115-S127-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationJournal Of Endodontics-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectAntimicrobial agents-
Palavras-chave: dc.subjectnatural compounds-
Palavras-chave: dc.subjectregenerative endodontics-
Palavras-chave: dc.subjectscoping review-
Título: dc.titleAntimicrobial Therapeutics in Regenerative Endodontics: A Scoping Review-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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