Anhedonic Type Behavior and Anxiety Profile of Wistar-UIS Rats Subjected to Chronic Social Isolation

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniv Pontificia Bolivariana-
Autor(es): dc.contributorUniversidade de Brasília (UnB)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorAcero-Castillo, Maria Camila-
Autor(es): dc.creatorArdila-Figueroa, Maria Camila-
Autor(es): dc.creatorBotelho de Oliveira, Silvia [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:56:27Z-
Data de disponibilização: dc.date.available2022-02-22T00:56:27Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-05-28-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fnbeh.2021.663761-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/209423-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/209423-
Descrição: dc.descriptionChronic Social Isolation (CSI) is a model of prolonged stress employed in a variety of studies to induce depression and anxious behavior in rats. The present study aims to evaluate the effect of CSI on male Wistar rats in terms of anhedonic-type behavior in the Sucrose Preference Test (SPT) and anxiogenic profile in the elevated-plus-maze (EPM) test, as well as evaluating the effect of resocialization upon sucrose consumption. A total of 24 adolescent male Wistar rats were evaluated. The animals were housed either together (communally) or socially isolated for 21 days, and then exposed for four consecutive days to the SPT test [water vs. a 32% sucrose solution (SS)]. Four days later, they were again subjected to the SPT test (32% vs. 0.7% SS), and then tested on the EPM apparatus 3 days later. Following the completion of the anxiogenic profile of the model, the animals were resocialized for 72 h and then re-tested once again using the SPT (32% vs. 0.7% SS). Twenty-four hours after this final consumption, the animals were euthanized to record the weight of their adrenal glands (AG). It was found that exposure to CSI produces anhedonic-type behavior and an anxiogenic profile in adolescent male rats, as evidenced in both the SPT and EPM tests, as well as in the animals' physiological stress response. It was also demonstrated that resocialization does not reverse the anhedonic-type behavior, nor the physiological response to stress.-
Descrição: dc.descriptionUniversidad Pontificia Bolivariana Seccional Bucaramanga-
Descrição: dc.descriptionUniv Pontificia Bolivariana, Sect Bucaramanga, Psychol, Santander, Colombia-
Descrição: dc.descriptionUniv Pontificia Bolivariana, Sect Bucaramanga, Neurosci & Behav, Santander, Colombia-
Descrição: dc.descriptionUniv Brasilia, Hlth Sci, Brasilia, DF, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Psychol, Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Psychobiol, Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Pontificia Bolivariana, Sect Bucaramanga, Fac Psychol, Santander, Colombia-
Descrição: dc.descriptionUniv Pontificia Bolivariana, Sect Bucaramanga, Lab Neurosci & Behav, Santander, Colombia-
Descrição: dc.descriptionUniv Estadual Paulista, Psychol, Sao Paulo, Brazil-
Formato: dc.format11-
Idioma: dc.languageen-
Publicador: dc.publisherFrontiers Media Sa-
Relação: dc.relationFrontiers In Behavioral Neuroscience-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectanhedonia-
Palavras-chave: dc.subjectanxiety-
Palavras-chave: dc.subjectdepression-
Palavras-chave: dc.subjectchronic social isolation-
Palavras-chave: dc.subjectresocialization-
Título: dc.titleAnhedonic Type Behavior and Anxiety Profile of Wistar-UIS Rats Subjected to Chronic Social Isolation-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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