The plasmidome of multidrug-resistant emergent Salmonella serovars isolated from poultry

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorTech Univ Denmark-
Autor(es): dc.creatorGaletti, Renata-
Autor(es): dc.creatorCasarin Penha Filho, Rafael Antonio [UNESP]-
Autor(es): dc.creatorFerreira, Joseane Cristina-
Autor(es): dc.creatorVarani, Alessandro M. [UNESP]-
Autor(es): dc.creatorSazinas, Pavelas-
Autor(es): dc.creatorJelsbak, Lars-
Autor(es): dc.creatorCosta Darini, Ana Lucia-
Data de aceite: dc.date.accessioned2022-02-22T00:55:58Z-
Data de disponibilização: dc.date.available2022-02-22T00:55:58Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.meegid.2021.104716-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/209302-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/209302-
Descrição: dc.descriptionThe rapid emergence of resistant bacteria is occurring worldwide. The understanding of the dissemination of antimicrobial resistance using high-throughput sequencing and bioinformatics approaches is providing valuable insights into the genetic basis of the horizontal gene transfer and the emergence of the antibiotic resistance threat. This ultimately can offer vital clues to the development of coordinated efforts to implement new policies to continue fighting against bacterial infections. The poultry microbiota is characterized as a potential reservoir of resistance genes, mostly derived from the Enterobacteriaceae which have become increasingly important in human and animal infections. In this work, complete genome sequences were achieved for four multidrugresistant Salmonella spp. isolated from poultry from different farms in Brazil. We identified highly similar IncHI2-ST2 megaplasmids (larger than 275.000 bp) in all Salmonella isolates studied. These megaplasmids carry a resistome comprised of eleven different resistance genes (aac(6?)-Iaa, aadA1b, aph(4)-Ia, aph(6)-Id, aph(3?)-Ib, aph(3?)-Ia, aac(3)-Iva, sul1, tetA, tetB and dfrA1b) and four heavy metal tolerance operons (telluride, mercury, silver and copper). In conclusion, the multidrug-resistant plasmids identified in S. enterica serovar Schwarzengrund and Newport isolated from poultry show a variety of antibiotic resistance and heavy metal tolerance genes, providing advantages for the bacteria to survive under extremely unfavorable conditions.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDanish Council for Independent Research-
Descrição: dc.descriptionUniv Sao Paulo, Fac Ciencias Fammceut Ribeirao Preto, Ave Cafe S-N, BR-14040903 Ribeirao Preto, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Fac Ciencias Agr & Vet, Jaboticabal, Brazil-
Descrição: dc.descriptionTech Univ Denmark, Lyngby, Denmark-
Descrição: dc.descriptionUniv Estadual Paulista, Fac Ciencias Agr & Vet, Jaboticabal, Brazil-
Descrição: dc.descriptionFAPESP: 2014/14494-8-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2015/11728-0-
Descrição: dc.descriptionFAPESP: 2017/26311-3-
Descrição: dc.descriptionDanish Council for Independent Research: 6108-00300A-
Formato: dc.format4-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationInfection Genetics And Evolution-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectPlasmids-
Palavras-chave: dc.subjectAntibiotic resistance-
Palavras-chave: dc.subjectHeavy metal tolerance-
Palavras-chave: dc.subjectPoultry-
Título: dc.titleThe plasmidome of multidrug-resistant emergent Salmonella serovars isolated from poultry-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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