Electrospun Poly(butylene-adipate-co-terephthalate)/Nano- hyDroxyapatite/Graphene Nanoribbon Scaffolds Improved the In Vivo Osteogenesis of the Neoformed Bone

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorAir Force Acad-
Autor(es): dc.contributorUFPI Fed Univ Piaui-
Autor(es): dc.contributorUniv Brasil-
Autor(es): dc.contributorUniv Fed Piaui-
Autor(es): dc.creatorReis Vasconcellos, Luana Marotta [UNESP]-
Autor(es): dc.creatorSantana-Melo, Gabriela E. [UNESP]-
Autor(es): dc.creatorSilva, Edmundo [UNESP]-
Autor(es): dc.creatorPereira, Vanessa Fernandes [UNESP]-
Autor(es): dc.creatorRibeiro Araujo, Juliani Caroline [UNESP]-
Autor(es): dc.creatorRosa Silva, Andre Diniz-
Autor(es): dc.creatorFurtado, Andre S. A.-
Autor(es): dc.creatorVaz Elias, Conceicao de Maria-
Autor(es): dc.creatorViana, Bartolomeu Cruz-
Autor(es): dc.creatorMarciano, Fernanda Roberta-
Autor(es): dc.creatorLobo, Anderson Oliveira-
Data de aceite: dc.date.accessioned2022-02-22T00:55:55Z-
Data de disponibilização: dc.date.available2022-02-22T00:55:55Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/jfb12010011-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/209286-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/209286-
Descrição: dc.descriptionElectrospun ultrathin fibrous scaffold filed with synthetic nanohydroxyapatite (nHAp) and graphene nanoribbons (GNR) has bioactive and osteoconductive properties and is a plausible strategy to improve bone regeneration. Poly(butylene-adipate-co-terephthalate) (PBAT) has been studied as fibrous scaffolds due to its low crystallinity, faster biodegradability, and good mechanical properties; however, its potential for in vivo applications remains underexplored. We proposed the application of electrospun PBAT with high contents of incorporated nHAp and nHAp/GNR nanoparticles as bone grafts. Ultrathin PBAT, PBAT/nHAp, and PBAT/nHAp/GNR fibers were produced using an electrospinning apparatus. The produced fibers were characterized morphologically and structurally using scanning electron (SEM) and high-resolution transmission electron (TEM) microscopies, respectively. Mechanical properties were analyzed using a texturometer. All scaffolds were implanted into critical tibia defects in rats and analyzed after two weeks using radiography, microcomputed tomography, histological, histomorphometric, and biomechanical analyses. The results showed through SEM and high-resolution TEM characterized the average diameters of the fibers (ranged from 0.208 mu m +/- 0.035 to 0.388 mu m +/- 0.087) and nHAp (crystallite around 0.28, 0.34, and 0.69 nm) and nHAp/GNR (200-300 nm) nanoparticles distribution into PBAT matrices. Ultrathin fibers were obtained, and the incorporated nHAp and nHAp/GNR nanoparticles were well distributed into PBAT matrices. The addition of nHAp and nHAp/GNR nanoparticles improved the elastic modulus of the ultrathin fibers compared to neat PBAT. High loads of nHAp/GNR (PBATnH5G group) improved the in vivo lamellar bone formation promoting greater radiographic density, trabecular number and stiffness in the defect area 2 weeks after implantation than control and PBAT groups.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionNational Council for Scientific and Technological Development-
Descrição: dc.descriptionSao Paulo State Univ, Inst Sci & Technol, Dept Biosci & Oral Diag, BR-12450000 Sao Paulo, Brazil-
Descrição: dc.descriptionAir Force Acad, Brazilian Air Force, BR-13630000 Pirassununga, Brazil-
Descrição: dc.descriptionUFPI Fed Univ Piaui, LIMAV Interdisciplinary Lab Adv Mat, BR-64049550 Teresina, Brazil-
Descrição: dc.descriptionUniv Brasil, Inst Cient & Tecnol, BR-12450000 Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Fed Piaui, Dept Phys, BR-64049550 Teresina, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Inst Sci & Technol, Dept Biosci & Oral Diag, BR-12450000 Sao Paulo, Brazil-
Descrição: dc.descriptionFAPESP: 2016/04618-7-
Descrição: dc.descriptionNational Council for Scientific and Technological Development: 310883/2020-2-
Descrição: dc.descriptionNational Council for Scientific and Technological Development: 404683/2018-AOL-
Descrição: dc.descriptionNational Council for Scientific and Technological Development: 311531/2020-2-
Formato: dc.format14-
Idioma: dc.languageen-
Publicador: dc.publisherMdpi-
Relação: dc.relationJournal Of Functional Biomaterials-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectelectrospinning-
Palavras-chave: dc.subjectnano-hydroxyapatite-
Palavras-chave: dc.subjectgraphene nanoribbons-
Palavras-chave: dc.subjectPBAT-
Palavras-chave: dc.subjectbone regeneration-
Título: dc.titleElectrospun Poly(butylene-adipate-co-terephthalate)/Nano- hyDroxyapatite/Graphene Nanoribbon Scaffolds Improved the In Vivo Osteogenesis of the Neoformed Bone-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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