The IS6 family, a clinically important group of insertion sequences including IS26

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorNanjing Univ-
Autor(es): dc.contributorUniv Paul SABATIER-
Autor(es): dc.contributorGeorgetown Univ-
Autor(es): dc.creatorVarani, Alessandro [UNESP]-
Autor(es): dc.creatorHe, Susu-
Autor(es): dc.creatorSiguier, Patricia-
Autor(es): dc.creatorRoss, Karen-
Autor(es): dc.creatorChandler, Michael-
Data de aceite: dc.date.accessioned2022-02-22T00:55:54Z-
Data de disponibilização: dc.date.available2022-02-22T00:55:54Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-03-23-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1186/s13100-021-00239-x-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/209279-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/209279-
Descrição: dc.descriptionThe IS6 family of bacterial and archaeal insertion sequences, first identified in the early 1980s, has proved to be instrumental in the rearrangement and spread of multiple antibiotic resistance. Two IS, IS26 (found in many enterobacterial clinical isolates as components of both chromosome and plasmids) and IS257 (identified in the plasmids and chromosomes of gram-positive bacteria), have received particular attention for their clinical impact. Although few biochemical data are available concerning the transposition mechanism of these elements, genetic studies have provided some interesting observations suggesting that members of the family might transpose using an unexpected mechanism. In this review, we present an overview of the family, the distribution and phylogenetic relationships of its members, their impact on their host genomes and analyse available data concerning the particular transposition pathways they may use. We also provide a mechanistic model that explains the recent observations on one of the IS6 family transposition pathways: targeted cointegrate formation between replicons.-
Descrição: dc.descriptionGlobal Emerging Infections Surveillance (GEIS) and Response System-
Descrição: dc.descriptionJiangsu Natural Science Foundation-
Descrição: dc.descriptionFundamental Research Funds for the Central Universities-
Descrição: dc.descriptionUniv Estadual Paulista, Sch Agr & Vet Sci, Jaboticabal, SP, Brazil-
Descrição: dc.descriptionNanjing Univ, State Key Lab Pharmaceut Biotechnol, Med Sch, Nanjing 210093, Jiangsu, Peoples R China-
Descrição: dc.descriptionUniv Paul SABATIER, Lab Microbiol & Genet Mol, CNRS, UMR Bat 5100,IBCG,Ctr Biol Integrat, Toulouse, France-
Descrição: dc.descriptionGeorgetown Univ, Med Ctr, Dept Biochem Mol & Cell, Prot Informat Resource, Washington, DC 20007 USA-
Descrição: dc.descriptionGeorgetown Univ, Dept Biochem Mol & Cell Biol, Med Ctr, Washington, DC 20007 USA-
Descrição: dc.descriptionUniv Estadual Paulista, Sch Agr & Vet Sci, Jaboticabal, SP, Brazil-
Descrição: dc.descriptionGlobal Emerging Infections Surveillance (GEIS) and Response System: P0020_18_WR-
Descrição: dc.descriptionJiangsu Natural Science Foundation: BK20200316-
Descrição: dc.descriptionFundamental Research Funds for the Central Universities: 14380470-
Formato: dc.format18-
Idioma: dc.languageen-
Publicador: dc.publisherBmc-
Relação: dc.relationMobile Dna-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectInsertion sequence-
Palavras-chave: dc.subjectPhylogeny-
Palavras-chave: dc.subjectGenome impact-
Palavras-chave: dc.subjectTransposition mechanisms-
Palavras-chave: dc.subjectClinical importance-
Palavras-chave: dc.subjectAntibiotic resistance-
Título: dc.titleThe IS6 family, a clinically important group of insertion sequences including IS26-
Aparece nas coleções:Repositório Institucional - Unesp

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