Topical formulations containing Copaifera duckei Dwyer oleoresin improve cutaneous wound healing

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniv Franca-
Autor(es): dc.contributorInst Fed Minas Gerais-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorGoncalves Dias, Fernanda Gosuen-
Autor(es): dc.creatorPereira, Lucas de Freitas-
Autor(es): dc.creatorFurtado, Ricardo Andrade-
Autor(es): dc.creatorMagalhaes, Georgia Mode-
Autor(es): dc.creatorMiguel, Marina Pacheco-
Autor(es): dc.creatorGosuen Goncalves Dias, Luis Gustavo [UNESP]-
Autor(es): dc.creatorJorge, Adriana Torrecilhas-
Autor(es): dc.creatorHonsho, Cristiane dos Santos-
Autor(es): dc.creatorAmbrosio, Sergio Ricardo-
Autor(es): dc.creatorBastos, Jairo Kenupp-
Autor(es): dc.creatorCarrijo, Micaela Silva-
Autor(es): dc.creatorTavares, Denise Crispim-
Data de aceite: dc.date.accessioned2022-02-22T00:55:39Z-
Data de disponibilização: dc.date.available2022-02-22T00:55:39Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-03-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/209197-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/209197-
Descrição: dc.descriptionObjective: Evaluation of the healing and toxicological effects of Copaifera duckei Dwyer oleoresin (CDO). Materials and Methods: Rodents with skin lesions were divided into nine groups, including daily treatments with 1, 3 and 10% CDO, collagenase, antibiotic ointment and control groups, for 14 days. Results: Treatment with 10% CDO reduced skin edema and hyperplasia, demonstrating anti-inflammatory effect of the oil. Reduction in the wound area was observed, indicating the healing effect of CDO. Histopathological analysis showed increases in angiogenesis and re-epithelialization in animals treated with the highest concentration. On the other hand, no alterations in ulcerations, inflammatory infiltrate, hemorrhage, congestion, degeneration, percentage of collagen fibers, number of cells stained with anti-macrophage migration inhibitory factor, or density of area stained with anti-collagen I and III were found. Toxicogenetic analysis revealed no differences in micronucleus frequencies or in the ratio of polychromatic eiythrocytes to total eiythrocytes between treated and negative control, demonstrating the absence of genotoxicity and cytotoxicity, respectively. There was no difference in levels of liver enzymes among groups, indicating the absence of hepatotoxicity. Conclusion: Formulations of CDO exerted beneficial effects on the stages of cutaneous wound healing and are promising options for the treatment of wounds.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionUniv Franca, Dept Vet Med, Franca, SP, Brazil-
Descrição: dc.descriptionInst Fed Minas Gerais, Dept Vet Med, Muzambinho, MG, Brazil-
Descrição: dc.descriptionUniv Fed Goias, Dept Vet Med, Goiania, Go, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Dept Vet Med, Jaboticabal, SP, Brazil-
Descrição: dc.descriptionUniv Franca, Dept Sci, Franca, SP, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Dept Pharm, Ribeirao Preto, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Dept Vet Med, Jaboticabal, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2011/13630-7-
Formato: dc.format120-133-
Idioma: dc.languageen-
Publicador: dc.publisherMashhad Univ Med Sciences-
Relação: dc.relationAvicenna Journal Of Phytomedicine-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectCutaneous wound healing-
Palavras-chave: dc.subjectCopaifera duckei Dwyer oleoresin-
Palavras-chave: dc.subjectToxicity-
Título: dc.titleTopical formulations containing Copaifera duckei Dwyer oleoresin improve cutaneous wound healing-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.