Increased oxidative stress and cancer biomarkers in the ventral prostate of older rats submitted to maternal malnutrition

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniv Calgary-
Autor(es): dc.contributorInst Nacl Ciencias Med & Nutr Salvador Zubiran-
Autor(es): dc.creatorPortela, Luiz M. F. [UNESP]-
Autor(es): dc.creatorSantos, Sergio A. A. [UNESP]-
Autor(es): dc.creatorConstantino, Flavia B. [UNESP]-
Autor(es): dc.creatorCamargo, Ana C. L. [UNESP]-
Autor(es): dc.creatorColombelli, Ketlin T. [UNESP]-
Autor(es): dc.creatorFioretto, Matheus N. [UNESP]-
Autor(es): dc.creatorBarquilha, Caroline N. [UNESP]-
Autor(es): dc.creatorPerico, Larissa L. [UNESP]-
Autor(es): dc.creatorHiruma-Lima, Clelia A. [UNESP]-
Autor(es): dc.creatorScarano, Wellerson R. [UNESP]-
Autor(es): dc.creatorZambrano, Elena-
Autor(es): dc.creatorJustulin, Luis A. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:55:34Z-
Data de disponibilização: dc.date.available2022-02-22T00:55:34Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.mce.2020.111148-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/209170-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/209170-
Descrição: dc.descriptionThe concept of Developmental Origins of Health and Disease (DOHaD) states that exposure to malnutrition early in life increase the incidence of non-communicable chronic diseases throughout the lifespan. In this study, a reduction in serum testosterone and an increase in estrogen levels were shown in older rats born to protein malnourished dams (6% protein in the diet) during gestation and lactation. Intraprostatic levels of reduced glutathione were decreased, while tissue expression of glutathione S-transferase pi and sulfiredoxin-1 were increased in these animals. Strong immunostaining for alfametilacil CoA racemase (AMACR), vascular endothelial growth factor-A (VEGF-A), and aquaporin-1 (AQP1) was also observed. In silica analysis confirmed commonly deregulated proteins in the ventral prostate of old rats and patients with prostate cancer. In conclusion, the increase in oxidative stress associated with an imbalance of sex hormones may contribute to prostate carcinogenesis in offspring, highlighting early-life malnutrition as a key risk factor for this malignance.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSao Paulo State Univ, Inst Biosci, Dept Struct & Funct Biol, Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Calgary, Cumming Sch Med, Snyder Inst Chron Dis, Calgary, AB, Canada-
Descrição: dc.descriptionInst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Biol Reprod, Mexico City, DF, Mexico-
Descrição: dc.descriptionSao Paulo State Univ, Inst Biosci, Dept Struct & Funct Biol, Botucatu, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2017/01063-7-
Descrição: dc.descriptionFAPESP: 2016/08789-0-
Descrição: dc.descriptionCNPq: 310663/2018-0-
Formato: dc.format9-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationMolecular And Cellular Endocrinology-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectDOHaD-
Palavras-chave: dc.subjectSex hormone imbalance-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectProstate diseases-
Palavras-chave: dc.subjectMaternal low protein diet-
Palavras-chave: dc.subjectAging-
Título: dc.titleIncreased oxidative stress and cancer biomarkers in the ventral prostate of older rats submitted to maternal malnutrition-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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