Antitumoral activity of micellar solutions containing allyl isothiocyanate: an in vitro study

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniv Fed Ouro Preto-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniv Fed Pelotas-
Autor(es): dc.creatorAlmeida, Tamires Cunha-
Autor(es): dc.creatorOliveira, Daiane Teixeira de-
Autor(es): dc.creatorVentura Savio, Andre Luiz [UNESP]-
Autor(es): dc.creatorPerasoli, Fernanda Barcante-
Autor(es): dc.creatorSilva, Glenda Nicioli da-
Autor(es): dc.creatorBarichello, Jose Mario-
Data de aceite: dc.date.accessioned2022-02-22T00:55:22Z-
Data de disponibilização: dc.date.available2022-02-22T00:55:22Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.30827/ars.v62i1.15845-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/209086-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/209086-
Descrição: dc.descriptionIntroduction: Several natural products exhibit promising antineoplastic activity against bladder cancer cells, including allyl isothiocyanate (AITC). However, the AITC irritates the mucous membranes and induces eczematous or vesicular skin reactions. Thus, pharmaceutical formulations are necessary to overcome these problems. The aim was to develop micellar solutions containing AITC and investigate their antitumoral activity in bladder carcinoma cell lines. Method: The micellar solutions were prepared by cold dispersion method. Subsequently, we evaluated cytotoxicity, cell proliferation, cell cycle kinetics and long-term effects of micelles in bladder cancer cells. Results: Cytotoxicity and cell proliferation assays showed there was an increase in AITC activity when it was encapsulated in micelles. We also observed cell cycle arrest in the S phase after treatment with AITC-micelles. Furthermore, the formulation was able to maintain the long-term effects of free AITC. Conclusions: The micellar solutions developed can become an interesting approach for administration of AITC in the treatment of bladder cancer.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)-
Descrição: dc.descriptionUniv Fed Ouro Preto, Lab Pesquisas Clin, Ouro Preto, Brazil-
Descrição: dc.descriptionUniv Fed Ouro Preto, Lab Bioquim & Biol Mol, Ouro Preto, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Lab Toxicogen & Nutrigen, Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Fed Ouro Preto, Lab Fitotecnol, Ouro Preto, Brazil-
Descrição: dc.descriptionUniv Fed Pelotas, Lab Tecnol Farmaceut, Pelotas, RS, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Lab Toxicogen & Nutrigen, Botucatu, SP, Brazil-
Descrição: dc.descriptionFAPEMIG: PPM-00282-11-
Descrição: dc.descriptionFAPEMIG: CBB-APQ-01497-14-
Formato: dc.format40-51-
Idioma: dc.languageen-
Publicador: dc.publisherUniv Granada, Editorial-
Relação: dc.relationArs Pharmaceutica-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectallyl isothiocyanate-
Palavras-chave: dc.subjectbladder cancer-
Palavras-chave: dc.subjectmicelles-
Palavras-chave: dc.subjectpoloxamer-
Título: dc.titleAntitumoral activity of micellar solutions containing allyl isothiocyanate: an in vitro study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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