A novel technique to produce tubular scaffolds based on collagen and elastin

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorNatl Inst Biofabricat-
Autor(es): dc.contributorNortheastern Univ-
Autor(es): dc.creatorRodrigues, Isabella C. P.-
Autor(es): dc.creatorPereira, Karina D. [UNESP]-
Autor(es): dc.creatorWoigt, Luiza F.-
Autor(es): dc.creatorJardini, Andre L.-
Autor(es): dc.creatorLuchessi, Augusto D. [UNESP]-
Autor(es): dc.creatorLopes, Eder S. N.-
Autor(es): dc.creatorWebster, Thomas J.-
Autor(es): dc.creatorGabriel, Lais P.-
Data de aceite: dc.date.accessioned2022-02-22T00:55:06Z-
Data de disponibilização: dc.date.available2022-02-22T00:55:06Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-11-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/aor.13857-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208997-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208997-
Descrição: dc.descriptionTubular polymer scaffolds based on tissue engineering techniques have been studied as potential alternatives for vascular regeneration implants. The blood vessels of the cardiovascular system are mainly fibrous, composed of collagen (Col) and elastin (El), and its inner layer consists of endothelial cells. In this work, Col and El were combined with polyurethane (PU), a biocompatible synthetic polymer, and rotary jet spinning, a new and highly productive technique, to produce fibrous scaffolds. The scaffolds produced at 18 000 rpm presented homogeneous, bead-free, and solvent-free fibers. The blend formation between PU-Col-El was identified by chemical composition analysis and enhanced the thermal stability up to 324 degrees C. The hydrophilic nature of the scaffold was revealed by its low contact angle. Cell viability of human umbilical vein endothelial cells with the scaffold was proven for 72 hours. The combined strategy of rotary jet spinning with a polymer blend containing Col and El was verified as an effective and promising alternative to obtain tubular scaffolds for tissue engineering on a large-scale production.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUniv Estadual Campinas, Sch Appl Sci, Rua Pedro Zaccaria 1300, BR-13484350 Limeira, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Campinas, Sch Mech Engn, Campinas, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Inst Biosci, Rio Claro, Brazil-
Descrição: dc.descriptionNatl Inst Biofabricat, Campinas, Brazil-
Descrição: dc.descriptionNortheastern Univ, Dept Chem Engn, Boston, MA 02115 USA-
Descrição: dc.descriptionSao Paulo State Univ, Inst Biosci, Rio Claro, Brazil-
Descrição: dc.descriptionFAPESP: 2017/13273-6-
Formato: dc.formatE113-E122-
Idioma: dc.languageen-
Publicador: dc.publisherWiley-Blackwell-
Relação: dc.relationArtificial Organs-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectbiomaterials-
Palavras-chave: dc.subjectcentrifugal spinning-
Palavras-chave: dc.subjectfiber-
Palavras-chave: dc.subjectmembranes-
Palavras-chave: dc.subjectpolyurethane-
Palavras-chave: dc.subjectproteins-
Palavras-chave: dc.subjecttubular scaffolds-
Título: dc.titleA novel technique to produce tubular scaffolds based on collagen and elastin-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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