The effect of prenatal cocaine exposure on the stress response of adult mice

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorAlbert Einstein Coll Med-
Autor(es): dc.contributorHarvard Med Sch-
Autor(es): dc.contributorMassachusetts Gen Hosp East-
Autor(es): dc.creatorPlaneta, Cleopatra S. [UNESP]-
Autor(es): dc.creatorBerliner, Jennifer-
Autor(es): dc.creatorRuss, Andrew-
Autor(es): dc.creatorKosofsky, Barry E.-
Data de aceite: dc.date.accessioned2022-02-22T00:54:33Z-
Data de disponibilização: dc.date.available2022-02-22T00:54:33Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2001-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/BF03033230-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208839-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208839-
Descrição: dc.descriptionThe neurotoxic consequences of intrauterine exposure to drugs of abuse, including cocaine, may include compromised fetal brain development with associated lasting behavioral alterations. Some infants exposed to cocainein utero demonstrate impairments in reactivity and altered behavioral responses to stressful conditions. Alterations in arousal regulation can impact on socialization, adaptation, and educability. Moreover, such alterations may render cocaine-exposed children more vulnerable to the adverse developmental impact of stressful situations, with implications for subsequent behavior and psychopathology.Animal models facilitate the independent analysis and identification of genetic, intrauterine, and postnatal environmental factors in contributing to cocaine-induced alterations in behavioral and neurochemical responses to stressors. Utilizing a prenatal mouse model of gestational cocaine exposure we have identified a behavioral alteration evident as decreased duration of footshock-induced immobility termed freezing in cocaine-exposed adults as compared with controls. However, this attenuated behavioral response was not accompanied by demonstrable alterations in corticosterone response, nor was the corticosterone response altered in cocaine-exposed adults following a more protracted restraint-induced stress. The dissociation of these behavioral and neurochemical indices of altered response to stressors may provide insights regarding brain mechanisms underlying alterations in behavioral reactivity to stressful conditions followingin utero cocaine exposure. In addition, this preclinical study may have implications for improved diagnostics and therapeutics for infants and children exposed to cocaine in the womb.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionPHS-
Descrição: dc.descriptionUniv Estadual Paulista, Fac Ciencias Farmaceut Araraquara, Sao Paulo, Brazil-
Descrição: dc.descriptionAlbert Einstein Coll Med, Bronx, NY USA-
Descrição: dc.descriptionHarvard Med Sch, Neurol, Boston, MA 02115 USA-
Descrição: dc.descriptionMassachusetts Gen Hosp East, Lab Mol & Dev Neurosci, 149 13th St, Charlestown, MA 02129 USA-
Descrição: dc.descriptionUniv Estadual Paulista, Fac Ciencias Farmaceut Araraquara, Sao Paulo, Brazil-
Descrição: dc.descriptionFAPESP: 94/1711-5-
Descrição: dc.descriptionPHS: DA00175-
Descrição: dc.descriptionPHS: DA08648-
Formato: dc.format53-64-
Idioma: dc.languageen-
Publicador: dc.publisherSpringer-
Relação: dc.relationNeurotoxicity Research-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectBrain Development-
Palavras-chave: dc.subjectCorticosterone-
Palavras-chave: dc.subjectDrugs of Abuse-
Palavras-chave: dc.subjectFootshock-induced Freezing-
Palavras-chave: dc.subjectHPA (Hypothalamic-
Palavras-chave: dc.subjectPituitary-
Palavras-chave: dc.subjectAdrenal) Axis-
Palavras-chave: dc.subjectMalnutrition-
Palavras-chave: dc.subjectPrenatal Cocaine-
Palavras-chave: dc.subjectRestraint Stress-
Título: dc.titleThe effect of prenatal cocaine exposure on the stress response of adult mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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