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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Università Cattolica del Sacro Cuore | - |
Autor(es): dc.contributor | Consiglio Nazionale delle Ricerche IBBA CNR | - |
Autor(es): dc.contributor | School of Veterinary Medicine | - |
Autor(es): dc.contributor | Collaborating Centre on Animal Genomics and Bioinformatics | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.creator | Del Corvo, Marcello | - |
Autor(es): dc.creator | Lazzari, Barbara | - |
Autor(es): dc.creator | Capra, Emanuele | - |
Autor(es): dc.creator | Zavarez, Ludmilla [UNESP] | - |
Autor(es): dc.creator | Milanesi, Marco [UNESP] | - |
Autor(es): dc.creator | Utsunomiya, Yuri Tani [UNESP] | - |
Autor(es): dc.creator | Utsunomiya, Adam Taiti Harth [UNESP] | - |
Autor(es): dc.creator | Stella, Alessandra | - |
Autor(es): dc.creator | de Paula Nogueira, Guilherme [UNESP] | - |
Autor(es): dc.creator | Garcia, Josè Fernando [UNESP] | - |
Autor(es): dc.creator | Ajmone-Marsan, Paolo | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:54:22Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:54:22Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-05-28 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.3389/fgene.2021.633132 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/208769 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/208769 | - |
Descrição: dc.description | Heat stress has a detrimental impact on cattle health, welfare and productivity by affecting gene expression, metabolism and immune response, but little is known on the epigenetic mechanisms mediating the effect of temperature at the cellular and organism level. In this study, we investigated genome-wide DNA methylation in blood samples collected from 5 bulls of the heat stress resilient Nellore breed and 5 bulls of the Angus that are more heat stress susceptible, exposed to the sun and high temperature-high humidity during the summer season of the Brazilian South-East region. The methylomes were analyzed during and after the exposure by Reduced Representation Bisulfite Sequencing, which provided genome-wide single-base resolution methylation profiles. Significant methylation changes between stressful and recovery periods were observed in 819 genes. Among these, 351 were only seen in Angus, 366 were specific to Nellore, and 102 showed significant changes in methylation patterns in both breeds. KEGG and Gene Ontology (GO) enrichment analyses showed that responses were breed-specific. Interestingly, in Nellore significant genes and pathways were mainly involved in stress responses and cellular defense and were under methylated during heat stress, whereas in Angus the response was less focused. These preliminary results suggest that heat challenge induces changes in methylation patterns in specific loci, which should be further scrutinized to assess their role in heat tolerance. | - |
Descrição: dc.description | Department of Animal Science Food and Nutrition – DIANA Nutrigenomics and Proteomics Research Centre – PRONUTRIGEN and Biodiversity and Ancient DNA Research Centre Università Cattolica del Sacro Cuore | - |
Descrição: dc.description | Istituto di Biologia e Biotecnologia Agraria Consiglio Nazionale delle Ricerche IBBA CNR | - |
Descrição: dc.description | School of Veterinary Medicine | - |
Descrição: dc.description | International Atomic Energy Agency Collaborating Centre on Animal Genomics and Bioinformatics | - |
Descrição: dc.description | Department of Production and Animal Health São Paulo State University (unesp) | - |
Descrição: dc.description | Department of Production and Animal Health São Paulo State University (unesp) | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Frontiers in Genetics | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | animals welfare | - |
Palavras-chave: dc.subject | cattle | - |
Palavras-chave: dc.subject | DNA methylation | - |
Palavras-chave: dc.subject | epigenetics | - |
Palavras-chave: dc.subject | heat stress | - |
Palavras-chave: dc.subject | red blood cell | - |
Título: dc.title | Methylome Patterns of Cattle Adaptation to Heat Stress | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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