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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade de São Paulo (USP) | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.creator | Luiz, Marcela Tavares | - |
Autor(es): dc.creator | Delello Di Filippo, Leonardo [UNESP] | - |
Autor(es): dc.creator | Tofani, Larissa Bueno [UNESP] | - |
Autor(es): dc.creator | de Araújo, Jennifer Thayanne Cavalcante [UNESP] | - |
Autor(es): dc.creator | Dutra, Jessyca Aparecida Paes [UNESP] | - |
Autor(es): dc.creator | Marchetti, Juliana Maldonado | - |
Autor(es): dc.creator | Chorilli, Marlus [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:54:19Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:54:19Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-07-15 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1016/j.ijpharm.2021.120758 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/208753 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/208753 | - |
Descrição: dc.description | Glioma is the most common type of Central Nervous System (CNS) neoplasia and it arises from glial cells. As glial cells are formed by different types of cells, glioma can be classified according to the cells that originate it or the malignancy grade. Glioblastoma multiforme is the most common and aggressive glioma. The high lethality of this tumor is related to the difficulty in performing surgical removal, chemotherapy, and radiotherapy in the CNS. To improve glioma treatment, a wide range of chemotherapeutics have been encapsulated in nanosystems to increase their ability to overcome the blood–brain barrier (BBB) and specifically reach the tumoral cells, reducing side effects and improving drug concentration in the tumor microenvironment. Several studies have investigated nanosystems covered with targeting ligands (e.g., proteins, peptides, aptamers, folate, and glucose) to increase the ability of drugs to cross the BBB and enhance their specificity to glioma through specific recognition by receptors on BBB and glioma cells. This review addresses the main targeting ligands used in nanosystems to overcome the BBB and promote the active targeting of drugs for glioma. Furthermore, the advantages of using these molecules in glioma treatment are discussed. | - |
Descrição: dc.description | School of Pharmaceutical Science of Ribeirao Preto University of Sao Paulo (USP) | - |
Descrição: dc.description | School of Pharmaceutical Science of Sao Paulo State University (UNESP) | - |
Descrição: dc.description | School of Pharmaceutical Science of Sao Paulo State University (UNESP) | - |
Idioma: dc.language | en | - |
Relação: dc.relation | International Journal of Pharmaceutics | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Active targeting | - |
Palavras-chave: dc.subject | Drug delivery systems | - |
Palavras-chave: dc.subject | Glioblastoma multiforme | - |
Palavras-chave: dc.subject | Nanoparticles | - |
Título: dc.title | Highlights in targeted nanoparticles as a delivery strategy for glioma treatment | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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