Oral delivery of micro/nanoparticulate systems based on natural polysaccharides for intestinal diseases therapy: Challenges, advances and future perspectives

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatordos Santos, Aline Martins [UNESP]-
Autor(es): dc.creatorCarvalho, Suzana Gonçalves [UNESP]-
Autor(es): dc.creatorMeneguin, Andréia Bagliotti [UNESP]-
Autor(es): dc.creatorSábio, Rafael Miguel [UNESP]-
Autor(es): dc.creatorGremião, Maria Palmira Daflon [UNESP]-
Autor(es): dc.creatorChorilli, Marlus [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:54:00Z-
Data de disponibilização: dc.date.available2022-02-22T00:54:00Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-10-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jconrel.2021.04.026-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208649-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208649-
Descrição: dc.descriptionColon-targeted oral delivery of drugs remains as an appealing and promising approach for the treatment of prevalent intestinal diseases (ID), such as inflammatory bowel disease (IBD) and colorectal cancer (CRC). Notwithstanding, there are numerous challenges to effective drug delivery to the colon, which requires the design of advanced strategies. Micro- and nanoparticles have received great attention as colon-targeted delivery platforms due to their reduced size and structural composition that favors the accumulation and/or residence time of drugs at the site of action and/or absorption, contributing to localized therapy. The choice by natural polysaccharides imparts key properties and advantages to the nano-in-microparticulate systems to effective colon-specific oral delivery. This review proposes to discuss the physiological barriers imposed by the gastrointestinal tract (GIT) against oral administration of drugs, as well as pathological factors and challenges of the ID for oral delivery of colon-targeted systems. We then provide an updated progress about polysaccharides-based colon-targeted drug delivery systems, including microparticulate, nanoparticulate and nano-in-microparticulate systems, highlighting their key properties, advantages and limitations to achieving targeted delivery and efficacious therapy within the colon. Lastly, we provide future perspectives, towards advances in the field and clinical translation of colon-targeted oral delivery systems for ID therapy.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences-
Descrição: dc.descriptionFAPESP: 2014/50928-2-
Descrição: dc.descriptionFAPESP: 2016/01464-9-
Descrição: dc.descriptionFAPESP: 2019/10761-5-
Descrição: dc.descriptionFAPESP: 2019/19817-3-
Descrição: dc.descriptionCNPq: 408244/2018-6-
Descrição: dc.descriptionCNPq: 465687/2014-8-
Formato: dc.format353-366-
Idioma: dc.languageen-
Relação: dc.relationJournal of Controlled Release-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectColon-targeted drug delivery-
Palavras-chave: dc.subjectColorectal cancer-
Palavras-chave: dc.subjectCrohn's disease-
Palavras-chave: dc.subjectInflammatory bowel disease-
Palavras-chave: dc.subjectMicro/nanoparticulate systems-
Palavras-chave: dc.subjectOral administration-
Palavras-chave: dc.subjectPolysaccharides-
Palavras-chave: dc.subjectUlcerative colitis-
Título: dc.titleOral delivery of micro/nanoparticulate systems based on natural polysaccharides for intestinal diseases therapy: Challenges, advances and future perspectives-
Aparece nas coleções:Repositório Institucional - Unesp

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