Antimicrobial effects of photodynamic therapy with Fotoenticine on Streptococcus mutans isolated from dental caries

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Vale do Paraiba/UNIVAP-
Autor(es): dc.contributorPhotonics Division of Institute of Advanced Studies (EFO-IEAv)-
Autor(es): dc.creatorTerra-Garcia, Maíra [UNESP]-
Autor(es): dc.creatorde Souza, Cheyenne Marçal [UNESP]-
Autor(es): dc.creatorFerreira Gonçalves, Nathalia Maria [UNESP]-
Autor(es): dc.creatorPereira, André Henrique Correia-
Autor(es): dc.creatorde Barros, Patrícia Pimentel [UNESP]-
Autor(es): dc.creatorBorges, Alessandra Bühler [UNESP]-
Autor(es): dc.creatorMiyakawa, Walter-
Autor(es): dc.creatorStrixino, Juliana Ferreira-
Autor(es): dc.creatorJunqueira, Juliana Campos [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:53:55Z-
Data de disponibilização: dc.date.available2022-02-22T00:53:55Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.pdpdt.2021.102303-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208619-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208619-
Descrição: dc.descriptionPhotodynamic therapy (PDT) is a promising strategy to control cariogenic pathogens, such as Streptococcus mutans. Seeking to reach the total bacterial elimination from dental surfaces, novel photosensitizers have been investigated, such as Fotoenticine (FTC) derived from chlorin e6. The objective of this study was to investigate the photodynamic effects of FTC against several clinical strains of S. mutans. Clinical isolates were obtained from patients with active carious lesions, identified by molecular analysis and subjected to PDT using laser irradiation (660 nm and 39.5 J/cm2) in planktonic and biofilm stages. We identified 11 S. mutans strains from cervical, occlusal and proximal caries. PDT mediated by FTC has totally eliminated the S. mutans cells in planktonic growth for all analyzed strains. In biofilms, PDT with FTC reached statistically significant reductions compared with the non-treated control group, at 5.4, 5.5 and 6.5 Log10 (CFU/mL), respectively, for the strains from proximal, occlusal and cervical caries. The scanning electron microscopy evaluations confirmed that PDT mediated by FTC was able to disaggregate and kill the S. mutans cells adhered to enamel surface, suggesting its potential to disinfect the dental tissues.-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University/UNESP-
Descrição: dc.descriptionPhotobiology Applied to Health Research and Development Institute IP&D University of Vale do Paraiba/UNIVAP-
Descrição: dc.descriptionDepartment of Restorative Dentistry Institute of Science and Technology São Paulo State University/UNESP-
Descrição: dc.descriptionPhotonics Division of Institute of Advanced Studies (EFO-IEAv)-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University/UNESP-
Descrição: dc.descriptionDepartment of Restorative Dentistry Institute of Science and Technology São Paulo State University/UNESP-
Idioma: dc.languageen-
Relação: dc.relationPhotodiagnosis and Photodynamic Therapy-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDental caries-
Palavras-chave: dc.subjectFotoenticine-
Palavras-chave: dc.subjectPhotodynamic therapy-
Palavras-chave: dc.subjectStreptococcus mutans-
Título: dc.titleAntimicrobial effects of photodynamic therapy with Fotoenticine on Streptococcus mutans isolated from dental caries-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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