Chemical and morphological effects of the contraceptive hormone 17 α-ethynylestradiol on fluid lipid membranes

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorItalian National Research Council (CNR-ISPA)-
Autor(es): dc.contributorS.P. Lecce-Monteroni-
Autor(es): dc.contributorUnità di Lecce-
Autor(es): dc.creatorRuiz, Gilia Cristine Marques [UNESP]-
Autor(es): dc.creatordo Carmo Morato, Luis Fernando [UNESP]-
Autor(es): dc.creatorPazin, Wallance Moreira [UNESP]-
Autor(es): dc.creatorMilano, Francesco-
Autor(es): dc.creatorConstantino, Carlos José Leopoldo [UNESP]-
Autor(es): dc.creatorValli, Ludovico-
Autor(es): dc.creatorGiotta, Livia-
Data de aceite: dc.date.accessioned2022-02-22T00:53:55Z-
Data de disponibilização: dc.date.available2022-02-22T00:53:55Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.colsurfb.2021.111794-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208618-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208618-
Descrição: dc.descriptionThe lack of studies involving the effects in human health associated with the chronic ingestion of pollutants lead to the path of investigating the action of these compounds in cell membrane models. We demonstrated the interaction (causes and consequences) of the hormone 17 α-ethinylestradiol (EE2) with lipid monolayers (prepared as Langmuir films) and bilayers prepared as small unilamellar vesicles (SUVs) and giant unilamellar vesicles (GUVs). Both fluidity and majority chemical composition of real plasma cell membrane were guaranteed using the phospholipid 1-palmitoil-2-oleoyl-sn-glycero-3-phosphatidylcholine (POPC). Surface pressure-mean molecular area (π-A) isotherms and PM-IRRAS measurements highlighted the strong interaction of EE2 with POPC monolayers, leading the hormone to remain at the air/water interface and promoting its penetration into the phospholipid hydrophobic chains. In the case of bilayers, the entrance of the hormone inside the SUV is likely facilitated by their high curvature. In GUVs, EE2 was responsible for changes in the spherical shape, forming structures like buds and lipid protrusions. The set of results indicates the strong effects of EE2 on fluid membranes, which is an important feature to predict its damage in human cells.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionInstituto Nacional de Ciência e Tecnologia em Eletrônica Orgânica-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Physics School of Technology and Applied Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Sciences of Food Production Italian National Research Council (CNR-ISPA), S.P. Lecce-Monteroni-
Descrição: dc.descriptionDepartment of Biological and Environmental Sciences and Technologies (DiSTeBA) University of Salento S.P. Lecce-Monteroni-
Descrição: dc.descriptionConsorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM) Unità di Lecce, S.P. Lecce-Monteroni-
Descrição: dc.descriptionDepartment of Physics School of Technology and Applied Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2016/09633-4-
Descrição: dc.descriptionFAPESP: 2018/222147-6-
Descrição: dc.descriptionCAPES: 88882.330129/2018-01-
Idioma: dc.languageen-
Relação: dc.relationColloids and Surfaces B: Biointerfaces-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject17α-ethynylestradiol-
Palavras-chave: dc.subjectGiant unilamellar vesicles-
Palavras-chave: dc.subjectLangmuir monolayers-
Palavras-chave: dc.subjectPM-IRRAS-
Palavras-chave: dc.subjectPOPC-
Palavras-chave: dc.subjectSmall unilamellar vesicles-
Título: dc.titleChemical and morphological effects of the contraceptive hormone 17 α-ethynylestradiol on fluid lipid membranes-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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