Detection of dysbiosis and increased intestinal permeability in brazilian patients with relapsing–remitting multiple sclerosis

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorSchool of Health Sciences Dr. Paulo Prata-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorDNA Consult Genetics and Biotechnology-
Autor(es): dc.contributorBarretos Cancer Hospital-
Autor(es): dc.contributorSao Carlos Federal University-
Autor(es): dc.creatorPellizoni, Felipe Papa-
Autor(es): dc.creatorLeite, Aline Zazeri [UNESP]-
Autor(es): dc.creatorRodrigues, Nathália de Campos-
Autor(es): dc.creatorUbaiz, Marcelo Jordão-
Autor(es): dc.creatorGonzaga, Marina Ignácio-
Autor(es): dc.creatorTakaoka, Nauyta Naomi Campos-
Autor(es): dc.creatorMariano, Vânia Sammartino-
Autor(es): dc.creatorOmori, Wellington Pine [UNESP]-
Autor(es): dc.creatorPinheiro, Daniel Guariz [UNESP]-
Autor(es): dc.creatorMatheucci Junior, Euclides-
Autor(es): dc.creatorGomes, Eleni [UNESP]-
Autor(es): dc.creatorde Oliveira, Gislane Lelis Vilela [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:53:54Z-
Data de disponibilização: dc.date.available2022-02-22T00:53:54Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijerph18094621-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208609-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208609-
Descrição: dc.descriptionDysbiosis, associated with barrier disruption and altered gut–brain communications, has been associated with multiple sclerosis (MS). In this study, we evaluated the gut microbiota in relapsing–remitting patients (RRMS) receiving disease-modifying therapies (DMTs) and correlated these data with diet, cytokines levels, and zonulin concentrations. Stool samples were used for 16S sequencing and real-time PCR. Serum was used for cytokine determination by flow cytometry, and zonulin quantification by ELISA. Pearson’s chi-square, Mann–Whitney, and Spearman’s correlation were used for statistical analyses. We detected differences in dietary habits, as well as in the gut microbiota in RRMS patients, with predominance of Akkermansia muciniphila and Bacteroides vulgatus and decreased Bifidobacterium. Interleukin-6 concentrations were decreased in treated patients, and we detected an increased intestinal permeability in RRMS patients when compared with controls. We conclude that diet plays an important role in the composition of the gut microbiota, and intestinal dysbiosis, detected in RRMS patients could be involved in increased intestinal permeability and affect the clinical response to DTMs. The future goal is to predict therapeutic responses based on individual microbiome analyses (personalized medicine) and propose dietary interventions and the use of probiotics or other microbiota modulators as adjuvant therapy to enhance the therapeutic efficacy of DMTs.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionMicrobiome Study Group School of Health Sciences Dr. Paulo Prata-
Descrição: dc.descriptionMicrobiology Program Institute of Biosciences Humanities and Exact Sciences São Paulo State University-
Descrição: dc.descriptionDNA Consult Genetics and Biotechnology-
Descrição: dc.descriptionBarretos Cancer Hospital-
Descrição: dc.descriptionDepartment of Technology School of Agricultural and Veterinarian Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionBiotechnology Department Sao Carlos Federal University-
Descrição: dc.descriptionFood Engineering and Technology Department São Paulo State University (UNESP)-
Descrição: dc.descriptionMicrobiology Program Institute of Biosciences Humanities and Exact Sciences São Paulo State University-
Descrição: dc.descriptionDepartment of Technology School of Agricultural and Veterinarian Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionFood Engineering and Technology Department São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2016/05062-2-
Descrição: dc.descriptionFAPESP: 2016/50204-0-
Descrição: dc.descriptionFAPESP: 2017/04508-0-
Descrição: dc.descriptionFAPESP: 2021/03866-5-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Environmental Research and Public Health-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAutoimmunity-
Palavras-chave: dc.subjectCytokines-
Palavras-chave: dc.subjectDisease modifying drugs-
Palavras-chave: dc.subjectDysbiosis-
Palavras-chave: dc.subjectGut microbiota-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectIntestinal permeability-
Palavras-chave: dc.subjectMultiple sclerosis-
Título: dc.titleDetection of dysbiosis and increased intestinal permeability in brazilian patients with relapsing–remitting multiple sclerosis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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