Benzenetriol-Derived Compounds against Citrus Canker

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Groningen-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorCavalca, Lúcia Bonci-
Autor(es): dc.creatorLahive, Ciaran W.-
Autor(es): dc.creatorGijsbers, Fleur-
Autor(es): dc.creatorPavan, Fernando Rogério [UNESP]-
Autor(es): dc.creatorScheffers, Dirk-Jan-
Autor(es): dc.creatorDeuss, Peter J.-
Data de aceite: dc.date.accessioned2022-02-22T00:53:47Z-
Data de disponibilização: dc.date.available2022-02-22T00:53:47Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-03-06-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/molecules26051436-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208573-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208573-
Descrição: dc.descriptionIn order to replace the huge amounts of copper salts used in citrus orchards, alternatives have been sought in the form of organic compounds of natural origin with activity against the causative agent of citrus canker, the phytopathogen Xanthomonas citri subsp. Citri. We synthesized a series of 4-alkoxy-1,2-benzene diols (alkyl-BDOs) using 1,2,4-benzenetriol (BTO) as a starting material through a three-step synthesis route and evaluated their suitability as antibacterial compounds. Our results show that alkyl ethers derived from 1,2,4-benzenetriol have bactericidal activity against X. citri, disrupting the bacterial cell membrane within 15 min. Alkyl-BDOs were also shown to remain active against the bacteria while in solution, and presented low toxicity to (human) MRC-5 cells. Therefore, we have demonstrated that 1,2,4-benzenetriol-a molecule that can be obtained from agricultural residues-is an adequate precursor for the synthesis of new compounds with activity against X. citri.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionNederlandse Organisatie voor Wetenschappelijk Onderzoek-
Descrição: dc.descriptionDepartment of Molecular Microbiology Groningen Biomolecular Sciences and Biotechnology Institute University of Groningen-
Descrição: dc.descriptionDepartment of Chemical Engineering (ENTEG) University of Groningen, Nijenborgh 4-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2017/50216-0-
Descrição: dc.descriptionNederlandse Organisatie voor Wetenschappelijk Onderzoek: 729.004.026-
Idioma: dc.languageen-
Relação: dc.relationMolecules (Basel, Switzerland)-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantimicrobials-
Palavras-chave: dc.subjectbio-based chemicals-
Palavras-chave: dc.subjectlignocellulosic biomass-
Palavras-chave: dc.subjectphenolic compounds-
Palavras-chave: dc.subjectXanthomonas citri-
Título: dc.titleBenzenetriol-Derived Compounds against Citrus Canker-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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