Genotoxicity induced by nerol, an essential oil present in citric plants using human peripheral blood mononuclear cells (PBMC) and HepG2/C3A cells as a model

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Trás-os-Montes and Alto Douro (UTAD)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorSilva, Brian Ogushi [UNESP]-
Autor(es): dc.creatorOrlando, Juliana Botinhon [UNESP]-
Autor(es): dc.creatorPires, Camila Lehnhardt [UNESP]-
Autor(es): dc.creatorHiruma-Lima, Clélia Akiko [UNESP]-
Autor(es): dc.creatorde Mascarenhas Gaivão, Isabel-
Autor(es): dc.creatorPerazzo, Fábio Ferreira-
Autor(es): dc.creatorMaistro, Edson Luis [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:53:41Z-
Data de disponibilização: dc.date.available2022-02-22T00:53:41Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/15287394.2021.1902443-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208535-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208535-
Descrição: dc.descriptionNerol (cis-3,7-dimethyl-2,6-octadien-1-ol) is a monoterpene widely used in cosmetic products, household detergents and cleaners, as well as a flavoring in several food products. Despite the high level of human exposure to nerol, an absence of studies regarding potential genetic toxicity in human cells exists. The aim of this investigation was to examine the cytotoxic and genotoxic potential of this monoterpene on human peripheral blood mononuclear cells as well as hepatic metabolizing HepG2/C3A human cell line. Cytotoxicity was assessed using trypan blue staining and MTT assay while genotoxicity was determined utilizing the comet and micronucleus test. Cytotoxicity tests showed cell viability greater than 70% for concentrations between 2.5 and 500 µg/ml. Both cell types exhibited significant DNA damage and chromosomal mutations after medium and high concentration incubation with nerol indicating that the safety of use of this monoterpene in various formulations to which humans are exposed needs to be monitored and requires more comprehensive investigations.-
Descrição: dc.descriptionSpeech and Hearing Therapy Department São Paulo State University – UNESP Faculty of Philosophy and Sciences-
Descrição: dc.descriptionPrograma De Pós-Graduação Em Biologia Geral E Aplicada – São Paulo State University (UNESP) Instituto De Biociências-
Descrição: dc.descriptionDepartment of Genetics and Biotechnology and Animal and Veterinary Research Centre (CECAV) University of Trás-os-Montes and Alto Douro (UTAD)-
Descrição: dc.descriptionInstitute of Environmental Chemistry and Pharmaceutical Sciences Federal University of São Paulo (UNIFESP)-
Descrição: dc.descriptionSpeech and Hearing Therapy Department São Paulo State University – UNESP Faculty of Philosophy and Sciences-
Descrição: dc.descriptionPrograma De Pós-Graduação Em Biologia Geral E Aplicada – São Paulo State University (UNESP) Instituto De Biociências-
Formato: dc.format518-528-
Idioma: dc.languageen-
Relação: dc.relationJournal of Toxicology and Environmental Health - Part A: Current Issues-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject6-octadien-1-ol-
Palavras-chave: dc.subject7-dimethyl-2-
Palavras-chave: dc.subjectCis-3-
Palavras-chave: dc.subjectclastogenic/aneugenic effects-
Palavras-chave: dc.subjectcomet assay-
Palavras-chave: dc.subjectmicronucleus test-
Palavras-chave: dc.subjectMTT assay-
Título: dc.titleGenotoxicity induced by nerol, an essential oil present in citric plants using human peripheral blood mononuclear cells (PBMC) and HepG2/C3A cells as a model-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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