Genome-wide scan reveals genomic regions and candidate genes underlying direct and maternal effects of preweaning calf mortality in Nellore cattle

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorNational Council for Science and Technological Development (CNPq)-
Autor(es): dc.creatorMarín-Garzón, N. A. [UNESP]-
Autor(es): dc.creatorMagalhães, A. F.B. [UNESP]-
Autor(es): dc.creatorSchmidt, P. I. [UNESP]-
Autor(es): dc.creatorSerna, M. [UNESP]-
Autor(es): dc.creatorFonseca, L. F.S. [UNESP]-
Autor(es): dc.creatorSalatta, B. M. [UNESP]-
Autor(es): dc.creatorFrezarim, G. B. [UNESP]-
Autor(es): dc.creatorFernandes-Júnior, G. A. [UNESP]-
Autor(es): dc.creatorBresolin, T. [UNESP]-
Autor(es): dc.creatorCarvalheiro, R. [UNESP]-
Autor(es): dc.creatorAlbuquerque, L. G. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:53:38Z-
Data de disponibilização: dc.date.available2022-02-22T00:53:38Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ygeno.2021.02.021-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208515-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208515-
Descrição: dc.descriptionWe conducted analysis to estimate genetic parameters and to identify genomic regions and candidate genes affecting direct and maternal effects of preweaning calf mortality (PWM) in Nellore cattle. Phenotypic records of 67,196 animals, and 8443 genotypes for 410,936 SNPs were used. Analysis were performed through the weighted single-step GBLUP approach and considering a threshold animal model via Bayesian Inference. Direct and maternal heritability estimates were of 0.2143 ± 0.0348 and 0.0137 ± 0.0066, respectively. The top 10 genomic regions accounted for 13.61 and 14.23% of the direct and maternal additive genetic variances and harbored a total of 63 and 91 positional candidate genes, respectively. Two overlapping regions on BTA2 were identified for both direct and maternal effects. Candidate genes are involved in biological mechanisms i.e. embryogenesis, immune response, feto-maternal communication, circadian rhythm, hormone alterations, myometrium adaptation, and milk secretion, which are critical for the successful calf growth and survival during preweaning period.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSão Paulo State University (Unesp) College of Agricultural and Veterinarian Sciences, Via de Acesso Professor Paulo Donato Castelane Castellane S/N - Vila Industrial-
Descrição: dc.descriptionNational Council for Science and Technological Development (CNPq)-
Descrição: dc.descriptionSão Paulo State University (Unesp) College of Agricultural and Veterinarian Sciences, Via de Acesso Professor Paulo Donato Castelane Castellane S/N - Vila Industrial-
Descrição: dc.descriptionFAPESP: #2017/10630-2-
Descrição: dc.descriptionFAPESP: #2018/20026-8-
Descrição: dc.descriptionCAPES: 001-
Formato: dc.format1386-1395-
Idioma: dc.languageen-
Relação: dc.relationGenomics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBeef cattle-
Palavras-chave: dc.subjectComplex traits-
Palavras-chave: dc.subjectGene interaction network-
Palavras-chave: dc.subjectHeritability-
Palavras-chave: dc.subjectSingle-step GWAS-
Palavras-chave: dc.subjectSurvival-
Título: dc.titleGenome-wide scan reveals genomic regions and candidate genes underlying direct and maternal effects of preweaning calf mortality in Nellore cattle-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.