Towards anti-angiogenic activity of NiFe2O4 nanoparticles

Registro completo de metadados
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorInstitute of Physical and Chemistry-
Autor(es): dc.creatorSantos, J. G. [UNESP]-
Autor(es): dc.creatorLopes, H. [UNESP]-
Autor(es): dc.creatorMoreno, H. [UNESP]-
Autor(es): dc.creatorRamirez, M. A. [UNESP]-
Autor(es): dc.creatorGarcia, F. G.-
Autor(es): dc.creatorSimões, A. Z. [UNESP]-
Data de aceite:
Data de disponibilização:
Data de envio:
Data de envio:
Data de envio:
Fonte completa do material: dc.identifier
Fonte completa do material: dc.identifier
Fonte: dc.identifier.uri
Descrição: dc.descriptionIn this study, NiFe2O4 nanoparticles (NPs) were prepared using the polymeric precursor method and calcined at 500°C for 4 h with (S– NiFe2O4) and without (NiFe2O4) CTAB as a surfactant, respectively. The magnetic and biological properties were evaluated based on the (micro)structure and electronic structure of the NPs. On sample S–NiFe2O4, the significant increase in magnetization saturation (Ms ~ 61.84 emu/g), magnetic remanence (Mr ~ 4.30 emu/g), and coercivity (Hc ~ 0.475 kOe) in comparison to sample NiFe2O4 (Ms ~ 24.81 emu/g, Mr ~ 1.00 emu/g, and Hc ~ 0.475 kOe) at room temperature (300 K) may be associated with the presence of oxygen vacancies the spinel lattice of NiFe2O4, generating magnetic moments. The concentration of 1 μg/mL S–NiFe2O4 decreased in ~50% angiogenesis in the chorioallantoic membrane (CAM). S–NiFe2O4 NPs showed high blood vessel affinity and anti-angiogenic activity; hence, effectively concentrating on tumoral vessels, which may enhance drug effectivity and enable simultaneous treatments, image diagnosis of solid tumors, etc. Thus, our results suggest that CTAB addition is an effective way to tune its magnetic response due to its excellent biocompatibility, high bulk saturation magnetization, and low magnetic anisotropy.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Engineering of Guaratinguetá-
Descrição: dc.descriptionFederal University of Itajubá (UNIFEI) Institute of Physical and Chemistry, Av. BPS, 1303-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Engineering of Guaratinguetá-
Descrição: dc.descriptionFAPESP: 2013/07296-2-
Descrição: dc.descriptionCNPq: 573636/2008-7-
Formato: dc.format16152-16161-
Idioma: dc.languageen-
Relação: dc.relationCeramics International-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnti-angiogenic-
Palavras-chave: dc.subjectNiFe2O4-
Palavras-chave: dc.subjectPolymeric precursor method-
Palavras-chave: dc.subjectSurfactant-
Título: dc.titleTowards anti-angiogenic activity of NiFe2O4 nanoparticles-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.