The role of CD68+ and CD163+ macrophages in immunopathogenesis of oral lichen planus and oral lichenoid lesions

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorFerrisse, Túlio Morandin [UNESP]-
Autor(es): dc.creatorde Oliveira, Analú Barros [UNESP]-
Autor(es): dc.creatorPalaçon, Mariana Paravani [UNESP]-
Autor(es): dc.creatorSilva, Evânio Vilela [UNESP]-
Autor(es): dc.creatorMassucato, Elaine Maria Sgavioli [UNESP]-
Autor(es): dc.creatorde Almeida, Luciana Yamamoto-
Autor(es): dc.creatorLéon, Jorge Esquiche-
Autor(es): dc.creatorBufalino, Andreia [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:53:33Z-
Data de disponibilização: dc.date.available2022-02-22T00:53:33Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.imbio.2021.152072-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208482-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208482-
Descrição: dc.descriptionMacrophages are phagocytic cells with essential participation in immunological events of the oral cavity. However, the role of these cells in oral lichen planus (OLP) and oral lichenoid lesions (OLL) remains unclear. The present study aimed to evaluate the density of macrophages in OLP and OLL, and to compare it with that of oral inflammatory fibrous hyperplasia (OIFH) (control group). 14 cases of OLP, 14 cases of OLL and 14 cases of OIFH were selected for immunohistochemical analysis of CD68+ (M1) and CD163+ (M2) macrophage expression. CD68+ and CD163+ macrophages densities were measured in the intraepithelial and subepithelial areas. The statistical tests used were multivariate analysis of variance, as well as a correlation and linear regression. OLP has more CD68+ macrophages when comparing with OLL (p = 0.001) and OIFH (p = 0.045). There is a very strong relationship between the macrophages types (p < 0.0001) in OLP and OLL. The linear regression showed that to OLL development (p < 0.0001/R2′ = 0.9584), the presence of different types of macrophages are more essential than to OLP (p < 0.0001/R2′ = 0.8983). However, in the OLP these dependencies are also largely. CD68+ macrophages may be associated with immunopathogenesis of OLP, indicating a pro-inflammatory activity and regulatory role in the type of T-cell response. Besides, CD68+ macrophages can cooperate in the diagnosis of OLP. These results are essential to future studies that seek a therapeutic target for OLP and OLL.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionOral Medicine Department of Diagnosis and Surgery São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionDepartment of Orthodontics and Pediatric Dentistry São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionDepartment of Pathology and Forensic Medicine Ribeirão Preto Medical Scholl (FMRP/USP) University of São Paulo-
Descrição: dc.descriptionOral Pathology Department of Stomatology Public Oral Health and Forensic Dentistry Ribeirão Preto Dental School (FORP/USP) University of São Paulo, Avenida do Café, S/N-
Descrição: dc.descriptionOral Medicine Department of Diagnosis and Surgery São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionDepartment of Orthodontics and Pediatric Dentistry São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionFAPESP: 2016/11419-0-
Descrição: dc.descriptionFAPESP: 2017/01438-0-
Descrição: dc.descriptionFAPESP: 2018/18440-0-
Descrição: dc.descriptionFAPESP: 2020/07110-0-
Descrição: dc.descriptionCNPq: 423945/2016-5-
Idioma: dc.languageen-
Relação: dc.relationImmunobiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectImmunohistochemistry-
Palavras-chave: dc.subjectImmunopathogenesis-
Palavras-chave: dc.subjectMacrophages-
Palavras-chave: dc.subjectMultivariate analysis-
Palavras-chave: dc.subjectOral lichen planus-
Palavras-chave: dc.subjectOral lichenoid lesion-
Palavras-chave: dc.subjectOral potentially malignant disorders-
Título: dc.titleThe role of CD68+ and CD163+ macrophages in immunopathogenesis of oral lichen planus and oral lichenoid lesions-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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