Centrally acting antihypertensives change the psychogenic cardiovascular reactivity

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Goias-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorMendonça, Michelle M.-
Autor(es): dc.creatorCosta, Amanda N.-
Autor(es): dc.creatorMoraes, Gean C.A.-
Autor(es): dc.creatorMartins, Gustavo M.-
Autor(es): dc.creatorAlmeida, Aline F.-
Autor(es): dc.creatorRincon, Gabriel C.N.-
Autor(es): dc.creatorSiqueira, João P.R.-
Autor(es): dc.creatorPadilha, Daniella M.-
Autor(es): dc.creatorMoya, Marcela I.-
Autor(es): dc.creatorFerreira-Neto, Marcos L.-
Autor(es): dc.creatorGomes, Rodrigo Mello-
Autor(es): dc.creatorPedrino, Gustavo Rodrigues-
Autor(es): dc.creatorFontes, Marco Antônio Peliky-
Autor(es): dc.creatorColombari, Eduardo [UNESP]-
Autor(es): dc.creatorCrestani, Carlos C. [UNESP]-
Autor(es): dc.creatorFajemiroye, James O.-
Autor(es): dc.creatorXavier, Carlos Henrique-
Data de aceite: dc.date.accessioned2022-02-22T00:53:28Z-
Data de disponibilização: dc.date.available2022-02-22T00:53:28Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/fcp.12648-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208462-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208462-
Descrição: dc.descriptionClonidine (CL) and Rilmenidine (RI) are among the most frequently prescribed centrally acting antihypertensives. Here, we compared CL and RI effects on psychogenic cardiovascular reactivity to sonant, luminous, motosensory, and vibrotactile stimuli during neurogenic hypertension. The femoral artery and vein of Wistar (WT – normotensive) and spontaneously hypertensive rats (SHR) were catheterized before (24 h interval) i.p. injection of vehicle (NaCl 0.9%, control - CT group), CL (10 µg/kg), or RI (10 µg/kg) and acute exposure to luminous (5000 lm), sonant (75 dB sudden tap), motor (180° cage twist), and air-jet (10 L/min – restraint and vibrotactile). Findings showed that: (i) CL or RI reduced the arterial pressure of SHR, without affecting basal heart rate in WT and SHR; (ii) different stimuli evoked pressor and tachycardic responses; (iii) CL and RI reduced pressor response to sound; (iv) CL or RI reduced pressor responses to luminous stimulus without a change in peak tachycardia in SHR; (v) cage twist increased blood pressure in SHR, which was attenuated by CL or RI; (vi) air-jet increased pressure and heart rate; (vii) CL or RI attenuated the pressor responses to air-jet in SHR while RI reduced the chronotropic reactivity in both strains. Altogether, both antihypertensives relieved the psychogenic cardiovascular responses to different stimuli. The RI elicited higher cardioprotective effects through a reduction in air-jet-induced tachycardia.-
Descrição: dc.descriptionInstitute of Biological Sciences Federal University of Goias-
Descrição: dc.descriptionSchool of Medicine Federal University of Goias-
Descrição: dc.descriptionInstitute of Biomedical Sciences Federal University of Uberlandia-
Descrição: dc.descriptionInstitute of Biological Sciences Federal University of Minas Gerais-
Descrição: dc.descriptionSchool of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationFundamental and Clinical Pharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectarousal-
Palavras-chave: dc.subjectdefense reactions-
Palavras-chave: dc.subjectheart rate-
Palavras-chave: dc.subjecthypertension-
Palavras-chave: dc.subjectstress-
Título: dc.titleCentrally acting antihypertensives change the psychogenic cardiovascular reactivity-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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