Bone regeneration assessment of polycaprolactone membrane on critical-size defects in rat calvaria

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorIbb University-
Autor(es): dc.contributorHarbin Medical University-
Autor(es): dc.creatorBassi, Ana Paula Farnezi [UNESP]-
Autor(es): dc.creatorBizelli, Vinícius Ferreira [UNESP]-
Autor(es): dc.creatorFrancatti, Tamires Mello [UNESP]-
Autor(es): dc.creatorde Moares Ferreira, Ana Carulina Rezende [UNESP]-
Autor(es): dc.creatorPereira, Járede Carvalho [UNESP]-
Autor(es): dc.creatorAl-Sharani, Hesham Mohammed-
Autor(es): dc.creatorLucas, Flavia de Almeida [UNESP]-
Autor(es): dc.creatorFaverani, Leonardo Perez [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:53:25Z-
Data de disponibilização: dc.date.available2022-02-22T00:53:25Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/membranes11020124-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208437-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208437-
Descrição: dc.descriptionBiomaterials for use in guided bone regeneration (GBR) are constantly being investigated and developed to improve clinical outcomes. The present study aimed to comparatively evaluate the biological performance of different membranes during the bone healing process of 8 mm critical defects in rat calvaria in order to assess their influence on the quality of the newly formed bone. Seventy-two adult male rats were divided into three experimental groups (n = 24) based on the membranes used: the CG—membrane-free control group (only blood clot, negative control), BG— porcine collagen membrane group (Bio-Guide®, positive control), and the PCL—polycaprolactone (enriched with 5% hydroxyapatite) membrane group (experimental group). Histological and his-tometric analyses were performed at 7, 15, 30, and 60 days postoperatively. The quantitative data were analyzed by two-way ANOVA and Tukey’s test (p < 0.05). At 7 and 15 days, the inflammatory responses in the BG and PCL groups were significantly different (p < 0.05). The PCL group, at 15 days, showed a large area of newly formed bone. At 30 and 60 days postoperatively, the PCL and BG groups exhibited similar bone healing, including some specimens showing complete closure of the critical defect (p = 0.799). Thus, the PCL membrane was biocompatible, and has the potential to help with GBR procedures.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University—UNESP-
Descrição: dc.descriptionSchool of Dentistry Faculty of Dentistry Ibb University-
Descrição: dc.descriptionDepartment of Maxillofacial Surgery School of Stomatology Harbin Medical University-
Descrição: dc.descriptionAraçatuba Veterinary Medicine School UNESP—São Paulo State University-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University—UNESP-
Descrição: dc.descriptionAraçatuba Veterinary Medicine School UNESP—São Paulo State University-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2014/24360-9-
Formato: dc.format1-12-
Idioma: dc.languageen-
Relação: dc.relationMembranes-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBone regeneration-
Palavras-chave: dc.subjectBone substitute-
Palavras-chave: dc.subjectMaterials biocompatibility-
Palavras-chave: dc.subjectMaterials testing-
Palavras-chave: dc.subjectMembranes-
Palavras-chave: dc.subjectPolycaprolactone-
Palavras-chave: dc.subjectPolymers-
Título: dc.titleBone regeneration assessment of polycaprolactone membrane on critical-size defects in rat calvaria-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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