Recent advances in drug discovery against Mycobacterium tuberculosis: Metal-based complexes

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUnion of the Colleges of the Great Lakes (UNILAGO)-
Autor(es): dc.creatorScarim, Cauê Benito [UNESP]-
Autor(es): dc.creatorLira de Farias, Renan [UNESP]-
Autor(es): dc.creatorVieira de Godoy Netto, Adelino [UNESP]-
Autor(es): dc.creatorChin, Chung Man [UNESP]-
Autor(es): dc.creatorLeandro dos Santos, Jean [UNESP]-
Autor(es): dc.creatorPavan, Fernando Rogério [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:53:14Z-
Data de disponibilização: dc.date.available2022-02-22T00:53:14Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-03-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ejmech.2021.113166-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208376-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208376-
Descrição: dc.descriptionMetal-based drugs are privileged motifs that act as primary pharmacophores in bioactive compounds for various diseases, including tuberculosis (TB). This potentially life-threatening and extremely contagious infectious disease is caused by Mycobacterium tuberculosis (Mtb). In 2018, TB infected about 10 million people and caused 1.2 million deaths worldwide. A large number of ligands are promising scaffolds in drug design, including heterocyclic, phosphines, schiff bases, thio and semicarbazones, aliphatic amines, cyclopalladated, cyanometallates and miscellaneous. Moreover, several metal-based complexes have been studied for the treatment of numerous illnesses, including infectious diseases. To contribute to drug design, we identified the metal-based organometallic complexes against Mtb. Thus, in this review article, we analysed the recent contributions of metal-based scaffolds for design of new anti-Mtb drugs in the last decade (2011–2020). Besides, metal-based approaches will be presented in order to find out new antitubercular agents.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionUniversidade Federal de Sergipe-
Descrição: dc.descriptionSao Paulo State University (UNESP) School of Pharmaceutical Sciences-
Descrição: dc.descriptionSao Paulo State University (UNESP) Institute of Chemistry-
Descrição: dc.descriptionSchool of Medicine Union of the Colleges of the Great Lakes (UNILAGO)-
Descrição: dc.descriptionSao Paulo State University (UNESP) School of Pharmaceutical Sciences-
Descrição: dc.descriptionSao Paulo State University (UNESP) Institute of Chemistry-
Idioma: dc.languageen-
Relação: dc.relationEuropean Journal of Medicinal Chemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDrug discovery-
Palavras-chave: dc.subjectMetal-based drugs-
Palavras-chave: dc.subjectMycobacterium tuberculosis-
Palavras-chave: dc.subjectTuberculosis-
Título: dc.titleRecent advances in drug discovery against Mycobacterium tuberculosis: Metal-based complexes-
Aparece nas coleções:Repositório Institucional - Unesp

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