Immunohistochemical evaluation of Langerhans cells in oral lichen planus and oral lichenoid lesions

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorFerrisse, Túlio Morandin [UNESP]-
Autor(es): dc.creatorde Oliveira, Analú Barros [UNESP]-
Autor(es): dc.creatorPalaçon, Mariana Paravani [UNESP]-
Autor(es): dc.creatorda Silveira, Heitor Albergoni [UNESP]-
Autor(es): dc.creatorMassucato, Elaine Maria Sgavioli [UNESP]-
Autor(es): dc.creatorde Almeida, Luciana Yamamoto-
Autor(es): dc.creatorLéon, Jorge Esquiche-
Autor(es): dc.creatorBufalino, Andreia [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:53:14Z-
Data de disponibilização: dc.date.available2022-02-22T00:53:14Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2020.105027-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208373-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208373-
Descrição: dc.descriptionObjective: the aim of this study was to evaluate the density of Langerhans cells in oral lichen planus (OLP) and oral lichenoid lesions (OLL). Design: 14 cases of OLP, 15 cases of OLL and 14 cases of oral inflammatory fibrous hyperplasia (OIFH), were selected for immunohistochemical analysis of CD1a, CD207 and S100 expression. The OIFH group was subdivided according to the presence (OIFHL n = 14) or absence (OIFHNL n = 14) of lichenoid inflammatory infiltrate. Positive cells were counted in intraepithelial and subepithelial areas. Results were analyzed by multivariate comparative analysis, correlation analysis, linear regression models and Student's T-test. Results: A significantly higher amount of CD207+ cells in OLL vs OLP was observed (p = 0.015). The prevailing reticular pattern observed was CD207high for OLP (p = 0.0329). A statistically significant difference in the expression of CD1a and CD207 was observed for intraepithelial vs subepithelial areas (p = 0.024 and p=0.015, for CD1a and CD207, respectively). Significant correlations were also observed between the expression of CD1a + and CD207+ cells in the pathogenesis of OLP and OLL. Conclusion: High levels of CD207+cells in OLP compared with OLL may help explain the differences in the immunopathogenesis of both diseases. Additionally, CD1a + and CD207+ cells appear to be more essential to immunopathogenesis of OLL than to the pathogenesis of OLP.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionOral Medicine Department of Diagnosis and Surgery São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionDepartment of Orthodontics and Pediatric Dentistry São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionDepartment of Pathology and Forensic Medicine Ribeirão Preto Medical Scholl (FMRP/USP) University of São Paulo-
Descrição: dc.descriptionOral Pathology Department of Stomatology Public Oral Health and Forensic Dentistry Ribeirão Preto Dental School (FORP/USP) University of São Paulo, Avenida do Café, S/N-
Descrição: dc.descriptionOral Medicine Department of Diagnosis and Surgery São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionDepartment of Orthodontics and Pediatric Dentistry São Paulo State University (UNESP) School of Dentistry-
Descrição: dc.descriptionFAPESP: 2016/11419-0-
Descrição: dc.descriptionFAPESP: 2017/01438-0-
Idioma: dc.languageen-
Relação: dc.relationArchives of Oral Biology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDendritic cells-
Palavras-chave: dc.subjectImmunohistochemistry-
Palavras-chave: dc.subjectLangerhans cells-
Palavras-chave: dc.subjectMultivariate analyses-
Palavras-chave: dc.subjectOral lichen planus-
Palavras-chave: dc.subjectRegression model-
Título: dc.titleImmunohistochemical evaluation of Langerhans cells in oral lichen planus and oral lichenoid lesions-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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