Prediction of SARS-CoV interaction with host proteins during lung aging reveals a potential role for TRIB3 in COVID-19

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorde Moraes, Diogo [UNESP]-
Autor(es): dc.creatorPaiva, Brunno Vivone Buquete [UNESP]-
Autor(es): dc.creatorCury, Sarah Santiloni [UNESP]-
Autor(es): dc.creatorLudwig, Raissa Guimarães-
Autor(es): dc.creatorJunior, João Pessoa Araújo [UNESP]-
Autor(es): dc.creatorda Silva Mori, Marcelo Alves-
Autor(es): dc.creatorCarvalho, Robson Francisco [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:53:13Z-
Data de disponibilização: dc.date.available2022-02-22T00:53:13Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.14336/AD.2020.1112-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208365-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208365-
Descrição: dc.descriptionCOVID-19 is prevalent in the elderly. Old individuals are more likely to develop pneumonia and respiratory failure due to alveolar damage, suggesting that lung senescence may increase the susceptibility to SARS-CoV-2 infection and replication. Considering that human coronavirus (HCoVs; SARS-CoV-2 and SARS-CoV) require host cellular factors for infection and replication, we analyzed Genotype-Tissue Expression (GTEx) data to test whether lung aging is associated with transcriptional changes in human protein-coding genes that potentially interact with these viruses. We found decreased expression of the gene tribbles homolog 3 (TRIB3) during aging in male individuals, and its protein was predicted to interact with HCoVs nucleocapsid protein and RNA-dependent RNA polymerase. Using publicly available lung single-cell data, we found TRIB3 expressed mainly in alveolar epithelial cells that express SARS-CoV-2 receptor ACE2. Functional enrichment analysis of age-related genes, in common with SARS-CoV-induced perturbations, revealed genes associated with the mitotic cell cycle and surfactant metabolism. Given that TRIB3 was previously reported to decrease virus infection and replication, the decreased expression of TRIB3 in aged lungs may help explain why older male patients are related to more severe cases of the COVID-19. Thus, drugs that stimulate TRIB3 expression should be evaluated as a potential therapy for the disease.-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionFaculty of Medicine São Paulo State University UNESP-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Biochemistry and Tissue Biology Institute of Biology State University of Campinas (UNICAMP)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionFaculty of Medicine São Paulo State University UNESP-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Biosciences São Paulo State University (UNESP)-
Formato: dc.format42-49-
Idioma: dc.languageen-
Relação: dc.relationAging and Disease-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectLung aging-
Palavras-chave: dc.subjectSARS-CoV-2-
Palavras-chave: dc.subjectTribbles homolog 3-
Palavras-chave: dc.subjectα-hydroxylinoleic acid-
Título: dc.titlePrediction of SARS-CoV interaction with host proteins during lung aging reveals a potential role for TRIB3 in COVID-19-
Tipo de arquivo: dc.typelivro digital-
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