Blocking IL-10 signaling with soluble IL-10 receptor restores in vitro specific lymphoproliferative response in dogs with leishmaniasis caused by Leishmania infantum

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Autor(es): dc.contributorTissue Engineering and Immunopharmacology Laboratory (LETI) or Pathology andMolecular Biology Laboratory (LPBM)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorSantos, Catiule de Oliveira-
Autor(es): dc.creatorCosta, Sidnei Ferro [UNESP]-
Autor(es): dc.creatorSouza, Fabiana Santana-
Autor(es): dc.creatorMendes, Jessica Mariane Ferreira-
Autor(es): dc.creatorPinheiro, Cristiane Garboggini Melo de-
Autor(es): dc.creatorMoreira, Diogo Rodrigo de Magalhães-
Autor(es): dc.creatorSilva, Luciano Kalabric-
Autor(es): dc.creatorLima, Valeria Marçal Felix de [UNESP]-
Autor(es): dc.creatorOliveira, Geraldo Gileno de Sá-
Data de aceite: dc.date.accessioned2022-02-22T00:53:12Z-
Data de disponibilização: dc.date.available2022-02-22T00:53:12Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0239171-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208362-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208362-
Descrição: dc.descriptionrIL-10 plays a major role in restricting exaggerated inflammatory and immune responses, thus preventing tissue damage. However, the restriction of inflammatory and immune responses by IL-10 can also favor the development and/or persistence of chronic infections or neoplasms. Dogs that succumb to canine leishmaniasis (CanL) caused by L. infantum develop exhaustion of T lymphocytes and are unable to mount appropriate cellular immune responses to control the infection. These animals fail to mount specific lymphoproliferative responses and produce interferon gamma and TNF-alpha that would activate macrophages and promote destruction of intracellular parasites. Blocking IL-10 signaling may contribute to the treatment of CanL. In order to obtain a tool for this blockage, the present work endeavored to identify the canine casIL-10R1 amino acid sequence, generate a recombinant baculovirus chromosome encoding this molecule, which was expressed in insect cells and subsequently purified to obtain rcasIL-10R1. In addition, rcasIL-10R1 was able to bind to homologous IL-10 and block IL-10 signaling pathway, as well as to promote lymphoproliferation in dogs with leishmaniasis caused by L. infantum.-
Descrição: dc.descriptionOswaldo Cruz Foundation Gonçalo Moniz Research Center Laboratory of Structural and MolecularPathology (LAPEM) Tissue Engineering and Immunopharmacology Laboratory (LETI) or Pathology andMolecular Biology Laboratory (LPBM)-
Descrição: dc.descriptionDepartment of Clinical Medicine Surgeryand Animal Reproduction São Paulo State University (UNESP) School of Veterinary Medicine-
Descrição: dc.descriptionDepartment of Clinical Medicine Surgeryand Animal Reproduction São Paulo State University (UNESP) School of Veterinary Medicine-
Idioma: dc.languageen-
Relação: dc.relationPLoS ONE-
???dc.source???: dc.sourceScopus-
Título: dc.titleBlocking IL-10 signaling with soluble IL-10 receptor restores in vitro specific lymphoproliferative response in dogs with leishmaniasis caused by Leishmania infantum-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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