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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Tissue Engineering and Immunopharmacology Laboratory (LETI) or Pathology andMolecular Biology Laboratory (LPBM) | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.creator | Santos, Catiule de Oliveira | - |
Autor(es): dc.creator | Costa, Sidnei Ferro [UNESP] | - |
Autor(es): dc.creator | Souza, Fabiana Santana | - |
Autor(es): dc.creator | Mendes, Jessica Mariane Ferreira | - |
Autor(es): dc.creator | Pinheiro, Cristiane Garboggini Melo de | - |
Autor(es): dc.creator | Moreira, Diogo Rodrigo de Magalhães | - |
Autor(es): dc.creator | Silva, Luciano Kalabric | - |
Autor(es): dc.creator | Lima, Valeria Marçal Felix de [UNESP] | - |
Autor(es): dc.creator | Oliveira, Geraldo Gileno de Sá | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:53:12Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:53:12Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2020-12-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1371/journal.pone.0239171 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/208362 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/208362 | - |
Descrição: dc.description | rIL-10 plays a major role in restricting exaggerated inflammatory and immune responses, thus preventing tissue damage. However, the restriction of inflammatory and immune responses by IL-10 can also favor the development and/or persistence of chronic infections or neoplasms. Dogs that succumb to canine leishmaniasis (CanL) caused by L. infantum develop exhaustion of T lymphocytes and are unable to mount appropriate cellular immune responses to control the infection. These animals fail to mount specific lymphoproliferative responses and produce interferon gamma and TNF-alpha that would activate macrophages and promote destruction of intracellular parasites. Blocking IL-10 signaling may contribute to the treatment of CanL. In order to obtain a tool for this blockage, the present work endeavored to identify the canine casIL-10R1 amino acid sequence, generate a recombinant baculovirus chromosome encoding this molecule, which was expressed in insect cells and subsequently purified to obtain rcasIL-10R1. In addition, rcasIL-10R1 was able to bind to homologous IL-10 and block IL-10 signaling pathway, as well as to promote lymphoproliferation in dogs with leishmaniasis caused by L. infantum. | - |
Descrição: dc.description | Oswaldo Cruz Foundation Gonçalo Moniz Research Center Laboratory of Structural and MolecularPathology (LAPEM) Tissue Engineering and Immunopharmacology Laboratory (LETI) or Pathology andMolecular Biology Laboratory (LPBM) | - |
Descrição: dc.description | Department of Clinical Medicine Surgeryand Animal Reproduction São Paulo State University (UNESP) School of Veterinary Medicine | - |
Descrição: dc.description | Department of Clinical Medicine Surgeryand Animal Reproduction São Paulo State University (UNESP) School of Veterinary Medicine | - |
Idioma: dc.language | en | - |
Relação: dc.relation | PLoS ONE | - |
???dc.source???: dc.source | Scopus | - |
Título: dc.title | Blocking IL-10 signaling with soluble IL-10 receptor restores in vitro specific lymphoproliferative response in dogs with leishmaniasis caused by Leishmania infantum | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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