Cyclotides from Brazilian Palicourea sessilis and Their Effects on Human Lymphocytes

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Queensland-
Autor(es): dc.contributorUniversity of Freiburg-
Autor(es): dc.contributorUniversity of Basel-
Autor(es): dc.contributorMedical University of Vienna-
Autor(es): dc.contributorRio de Janeiro Botanic Garden Research Institute-JBRJ-
Autor(es): dc.creatorPinto, Meri Emili F. [UNESP]-
Autor(es): dc.creatorChan, Lai Yue-
Autor(es): dc.creatorKoehbach, Johannes-
Autor(es): dc.creatorDevi, Seema-
Autor(es): dc.creatorGründemann, Carsten-
Autor(es): dc.creatorGruber, Christian W.-
Autor(es): dc.creatorGomes, Mario-
Autor(es): dc.creatorBolzani, Vanderlan S. [UNESP]-
Autor(es): dc.creatorCilli, Eduardo Maffud [UNESP]-
Autor(es): dc.creatorCraik, David J.-
Data de aceite: dc.date.accessioned2022-02-22T00:53:11Z-
Data de disponibilização: dc.date.available2022-02-22T00:53:11Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-01-21-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1021/acs.jnatprod.0c01069-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208356-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208356-
Descrição: dc.descriptionCyclotides are plant-derived peptides found within five families of flowering plants (Violaceae, Rubiaceae, Fabaceae, Solanaceae, and Poaceae) that have a cyclic backbone and six conserved cysteine residues linked by disulfide bonds. Their presence within the Violaceae species seems ubiquitous, yet not all members of other families produce these macrocyclic peptides. The genus Palicourea Aubl. (Rubiaceae) contains hundreds of neotropical species of shrubs and small trees; however, only a few cyclotides have been discovered hitherto. Herein, five previously uncharacterized Möbius cyclotides within Palicourea sessilis and their pharmacological activities are described. Cyclotides were isolated from leaves and stems of this plant and identified as pase A-E, as well as the known peptide kalata S. Cyclotides were de novo sequenced by MALDI-TOF/TOF mass spectrometry, and their structures were solved by NMR spectroscopy. Because some cyclotides have been reported to modulate immune cells, pase A-D were assayed for cell proliferation of human primary activated T lymphocytes, and the results showed a dose-dependent antiproliferative function. The toxicity on other nonimmune cells was also assessed. This study reveals that pase cyclotides have potential for applications as immunosuppressants and in immune-related disorders.-
Descrição: dc.descriptionInstitute of Chemistry Saõ Paulo State University UNESP-
Descrição: dc.descriptionInstitute for Molecular Bioscience Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science University of Queensland-
Descrição: dc.descriptionInstitute for Infection Prevention and Hospital Epidemiology Center for Complementary Medicine University of Freiburg-
Descrição: dc.descriptionTranslational Complementary Medicine Department of Pharmaceutical Sciences University of Basel-
Descrição: dc.descriptionCenter for Physiology and Pharmacology Medical University of Vienna-
Descrição: dc.descriptionRio de Janeiro Botanic Garden Research Institute-JBRJ-
Descrição: dc.descriptionInstitute of Chemistry Saõ Paulo State University UNESP-
Formato: dc.format81-90-
Idioma: dc.languageen-
Relação: dc.relationJournal of Natural Products-
???dc.source???: dc.sourceScopus-
Título: dc.titleCyclotides from Brazilian Palicourea sessilis and Their Effects on Human Lymphocytes-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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