Thiamethoxam exposure deregulates short ORF gene expression in the honey bee and compromises immune response to bacteria

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Birmingham-
Autor(es): dc.contributorUniversity of Nottingham-
Autor(es): dc.creatorDecio, Pâmela [UNESP]-
Autor(es): dc.creatorUstaoglu, Pinar-
Autor(es): dc.creatorDerecka, Kamila-
Autor(es): dc.creatorHardy, Ian C. W.-
Autor(es): dc.creatorRoat, Thaisa C. [UNESP]-
Autor(es): dc.creatorMalaspina, Osmar [UNESP]-
Autor(es): dc.creatorMongan, Nigel-
Autor(es): dc.creatorStöger, Reinhard-
Autor(es): dc.creatorSoller, Matthias-
Data de aceite: dc.date.accessioned2022-02-22T00:53:11Z-
Data de disponibilização: dc.date.available2022-02-22T00:53:11Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-020-80620-7-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208354-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208354-
Descrição: dc.descriptionMaximizing crop yields relies on the use of agrochemicals to control insect pests. One of the most widely used classes of insecticides are neonicotinoids that interfere with signalling of the neurotransmitter acetylcholine, but these can also disrupt crop-pollination services provided by bees. Here, we analysed whether chronic low dose long-term exposure to the neonicotinoid thiamethoxam alters gene expression and alternative splicing in brains of Africanized honey bees, Apis mellifera, as adaptation to altered neuronal signalling. We find differentially regulated genes that show concentration-dependent responses to thiamethoxam, but no changes in alternative splicing. Most differentially expressed genes have no annotated function but encode short Open Reading Frames, a characteristic feature of anti-microbial peptides. As this suggested that immune responses may be compromised by thiamethoxam exposure, we tested the impact of thiamethoxam on bee immunity by injecting bacteria. We show that intrinsically sub-lethal thiamethoxam exposure makes bees more vulnerable to normally non-pathogenic bacteria. Our findings imply a synergistic mechanism for the observed bee population declines that concern agriculturists, conservation ecologists and the public.-
Descrição: dc.descriptionBiotechnology and Biological Sciences Research Council-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (Unesp)-
Descrição: dc.descriptionSchool of Biosciences College of Life and Environmental Sciences University of Birmingham, Edgbaston-
Descrição: dc.descriptionSchool of Biosciences University of Nottingham, Sutton Bonington-
Descrição: dc.descriptionSchool of Veterinary Medicine and Science University of Nottingham, Sutton Bonington-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (Unesp)-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titleThiamethoxam exposure deregulates short ORF gene expression in the honey bee and compromises immune response to bacteria-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.