Disrupted nocturnal melatonin in autism: Association with tumor necrosis factor and sleep disturbances

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Marilia (UNIMAR)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorCRC Scotland & London-
Autor(es): dc.creatorda Silveira Cruz-Machado, Sanseray-
Autor(es): dc.creatorGuissoni Campos, Leila Maria-
Autor(es): dc.creatorFadini, Cintia Cristina [UNESP]-
Autor(es): dc.creatorAnderson, George-
Autor(es): dc.creatorMarkus, Regina P.-
Autor(es): dc.creatorPinato, Luciana [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:53:08Z-
Data de disponibilização: dc.date.available2022-02-22T00:53:08Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/jpi.12715-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208339-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208339-
Descrição: dc.descriptionSleep disturbances, abnormal melatonin secretion, and increased inflammation are aspects of autism spectrum disorder (ASD) pathophysiology. The present study evaluated the daily urinary 6-sulfatoxymelatonin (aMT6s) excretion profile and the salivary levels of tumor necrosis factor (TNF) and interleukin-6 (IL-6) in 20 controls and 20 ASD participants, as well as correlating these measures with sleep disturbances. Although 60% of ASD participants showed a significant night-time rise in aMT6s excretion, this rise was significantly attenuated, compared to controls (P <.05). The remaining 40% of ASD individuals showed no significant increase in nocturnal aMT6s. ASD individuals showed higher nocturnal levels of saliva TNF, but not IL-6. Dysfunction in the initiation and maintenance of sleep, as indicated by the Sleep Disturbance Scale for Children, correlated with night-time aMT6s excretion (r = −.28, P <.05). Dysfunction in sleep breathing was inversely correlated with aMT6s (r = −.31, P <.05) and positively associated with TNF level (r =.42, P <.01). Overall such data indicate immune-pineal axis activation, with elevated TNF but not IL-6 levels associated with disrupted pineal melatonin release and sleep dysfunction in ASD. It is proposed that circadian dysregulation in ASD is intimately linked to heightened immune-inflammatory activity. Such two-way interactions of the immune-pineal axis may underpin many aspects of ASD pathophysiology, including sleep disturbances, as well as cognitive and behavioral alterations.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionLaboratory of Chronopharmacology Department of Physiology Institute of Biosciences University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Anatomy School of Medicine University of Marilia (UNIMAR)-
Descrição: dc.descriptionDepartment of Speech Language and Hearing Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionCRC Scotland & London-
Descrição: dc.descriptionDepartment of Speech Language and Hearing Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2011/15713-7-
Descrição: dc.descriptionFAPESP: 2011/51495-4-
Descrição: dc.descriptionFAPESP: 2015/04557-5-
Idioma: dc.languageen-
Relação: dc.relationJournal of Pineal Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject6-sulfatoxymelatonin-
Palavras-chave: dc.subjectautism spectrum disorder-
Palavras-chave: dc.subjectbehavior-
Palavras-chave: dc.subjectcytokines-
Palavras-chave: dc.subjectimmune-pineal axis-
Palavras-chave: dc.subjectmelatonin-
Palavras-chave: dc.subjectneuroinflammation-
Título: dc.titleDisrupted nocturnal melatonin in autism: Association with tumor necrosis factor and sleep disturbances-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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