Impact of combined long-term fructose and prednisolone intake on glucose and lipid homeostasis in rats: benefits of intake interruption or fish oil administration

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Autor(es): dc.contributorUniversidade Federal de Santa Catarina (UFSC)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorSantos, Cristiane dos-
Autor(es): dc.creatorda Silva, Julia Spanhol-
Autor(es): dc.creatorBrunetta, Henver Simionato-
Autor(es): dc.creatorChagas, Thays Rodrigues-
Autor(es): dc.creatorZoccal, Daniel Breseghello [UNESP]-
Autor(es): dc.creatorNunes, Everson Araújo-
Autor(es): dc.creatorRafacho, Alex-
Data de aceite: dc.date.accessioned2022-02-22T00:53:07Z-
Data de disponibilização: dc.date.available2022-02-22T00:53:07Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jnutbio.2020.108572-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208332-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208332-
Descrição: dc.descriptionWe investigated whether combined long-term fructose and prednisolone intake would be more detrimental to the glucose homeostasis than if ingested separately. We also evaluated whether fish oil administration or interruption of treatments has any positive impact. For this, male adult Wistar rats ingested fructose (20%) (F) or prednisolone (12.5 µg/mL) (P) or both (FP) through drinking water for 12 weeks. A separate group of fructose and prednisolone-treated rats received fish oil treatment (1 g/kg) in the last 6 weeks. In another group, the treatment with fructose and prednisolone was interrupted after 12 weeks, and the animals were followed for more 12 weeks. Control groups ran in parallel (C). The F group had higher plasma TG (+42%) and visceral adiposity (+63%), whereas the P group had lower insulin sensitivity (−33%) and higher insulinemia (+200%). Only the the FP group developed these alterations combined with higher circulating uric acid (+126%), hepatic triacylglycerol content (+16.2-fold), lipid peroxidation (+173%) and lower catalase activity (−32%) that were associated with lower protein kinase B content and AMP-activated protein kinase (AMPK) phosphorylation in the liver, lower AMPK phosphorylation in the adipose tissue and higher beta-cell mass. Fish oil ingestion attenuated the elevation in circulating triacylglycerol and uric acid values, while the interruption of sugar and glucocorticoid intake reverted almost all modified parameters. In conclusion, long-term intake of fructose and prednisolone by male rats are more detrimental to glucose and lipid homeostasis than if ingested separately and the benefits of treatment interruption are broader than fish oil treatment.-
Descrição: dc.descriptionLaboratory of Investigation in Chronic Diseases - LIDoC Department of Physiological Sciences Centre of Biological Sciences Federal University of Santa Catarina - UFSC-
Descrição: dc.descriptionMulticentre Graduate Program in Physiological Sciences Centre of Biological Sciences Federal University of Santa Catarina - UFSC-
Descrição: dc.descriptionGraduate Program in Nutrition Centre of Health Sciences Federal University of Santa Catarina - UFSC-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry São Paulo State University - UNESP-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry São Paulo State University - UNESP-
Idioma: dc.languageen-
Relação: dc.relationJournal of Nutritional Biochemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectFructose-
Palavras-chave: dc.subjectGlucocorticoids-
Palavras-chave: dc.subjectMetabolic syndrome-
Palavras-chave: dc.subjectMetabolism-
Palavras-chave: dc.subjectSweetened beverages-
Título: dc.titleImpact of combined long-term fructose and prednisolone intake on glucose and lipid homeostasis in rats: benefits of intake interruption or fish oil administration-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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