Analgesic and anti-inflammatory articular effects of essential oil and camphor isolated from Ocimum kilimandscharicum Gürke leaves

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Grande Dourados-
Autor(es): dc.contributorUniversity Center of Grande Dourados (UNIGRAN)-
Autor(es): dc.contributorFederal University of Mato Grosso do Sul-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Estadual de Maringá (UEM)-
Autor(es): dc.creatordos Santos, Elisangela-
Autor(es): dc.creatorLeitão, Maicon Matos-
Autor(es): dc.creatorAguero Ito, Caren Naomi-
Autor(es): dc.creatorSilva-Filho, Saulo Euclides-
Autor(es): dc.creatorArena, Arielle Cristina [UNESP]-
Autor(es): dc.creatorSilva-Comar, Francielli Maria de Souza-
Autor(es): dc.creatorNakamura Cuman, Roberto Kenji-
Autor(es): dc.creatorOliveira, Rodrigo Juliano-
Autor(es): dc.creatorNazari Formagio, Anelise Samara-
Autor(es): dc.creatorLeite Kassuya, Cândida Aparecida-
Data de aceite: dc.date.accessioned2022-02-22T00:53:00Z-
Data de disponibilização: dc.date.available2022-02-22T00:53:00Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-04-06-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jep.2020.113697-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208289-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208289-
Descrição: dc.descriptionEthnopharmacological relevance: Leaves from Ocimum kilimandscharicum Gürke (Lamiaceae) are popularly used against articular pain. Aim of study: The aim of this study was to test the anti-inflammatory and anti-hyperalgesic (analgesic) properties of the essential oil and camphor isolated from O. Kilimandscharicum leaves (EOOK) in 4 models including zymosan induced-articular inflammation model in mice. Material and methods: For in vivo models, EOOK was tested in carrageenan-induced paw edema model with oral doses of 30, 100, and 300 mg/kg (oral administration = p.o.) and in zymosan-induced articular inflammation (including knee edema, leukocyte infiltration, mechanical hyperalgesia and nitric oxide), EOOK (100 mg/kg, p. o.) and camphor (30 mg/kg, p. o.) were tested. EOOK (100 mg/kg, p. o.) was tested in the rolling and also in the adhesion of leukocytes to the mesenteric microcirculation in situ model of carrageenan induced inflammation and EOOK (1, 3, 10, 30, and 60 μg/mL) was tested in vitro against neutrophils chemotaxis induced by N-formyl methionyl leucyl phenylalanine (fMLP). Results: The treatment with EOOK significantly inhibited the carrageenan-induced edema, mechanical and cold hyperalgesia. Both, EOOK and camphor inhibited all articular parameters induced by zymosan. In situ intravitral microscopy analysis, EOOK significantly inhibited carrageenan-induced leukocyte rolling and adhesion. In vitro neutrophils chemotaxis, EOOK inhibited the leukocyte chemotaxis induced by fMLP. Conclusions: The present study showed that EOOK inhibited pain and inflammatory parameters contributing, at least in part, to explain the popular use of this plant as analgesic natural agent. This study also demonstrates that camphor and some known anti-inflammatory compounds present in EOOK could contribute for analgesic and anti-inflammatory articular properties.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul-
Descrição: dc.descriptionSchool of Health Sciences Federal University of Grande Dourados-
Descrição: dc.descriptionSchool of Health Sciences University Center of Grande Dourados (UNIGRAN)-
Descrição: dc.descriptionPharmaceutical Sciences Food and Nutrition College Federal University of Mato Grosso do Sul-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartment of Pharmacology and Therapeutics State University of Maringá (UEM)-
Descrição: dc.descriptionSchool of Medicine Federal University of Mato Grosso do Sul-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionFundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul: 59/300.130/2016-
Idioma: dc.languageen-
Relação: dc.relationJournal of Ethnopharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnti-hyperalgesic-
Palavras-chave: dc.subjectArticular-
Palavras-chave: dc.subjectCamphor-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectJoint-
Palavras-chave: dc.subjectOcimum kilimandscharicum-
Título: dc.titleAnalgesic and anti-inflammatory articular effects of essential oil and camphor isolated from Ocimum kilimandscharicum Gürke leaves-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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