Electrical stimulation enhances early palatal wound healing in mice

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorFEI – College of Industrial Engineering-
Autor(es): dc.contributorSchool of Dentistry-
Autor(es): dc.creatorFerreira, Camila Lopes [UNESP]-
Autor(es): dc.creatorNeves Jardini, Maria Aparecida [UNESP]-
Autor(es): dc.creatorMoretto Nunes, Camilla Magnoni [UNESP]-
Autor(es): dc.creatorBernardo, Daniella Vicensotto [UNESP]-
Autor(es): dc.creatorViana Casarin, Renato Corrêa-
Autor(es): dc.creatordos Santos Gedraite, Estevão-
Autor(es): dc.creatorMathias, Márcio Antônio-
Autor(es): dc.creatorLiu, Fei-
Autor(es): dc.creatorMendonça, Gustavo-
Autor(es): dc.creatorSilveira Mendonça, Daniela Baccelli-
Autor(es): dc.creatorSantamaria, Mauro Pedrine [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:52:59Z-
Data de disponibilização: dc.date.available2022-02-22T00:52:59Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2020.105028-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208284-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208284-
Descrição: dc.descriptionBackground/objective: Electrical stimulation (ES) has been used to treat chronic wound and other clinical applications, showing favorable results in wound closure. It was hypothesized that ES can present a positive effect on oral mucosa healing. The aim of this study was to investigate the effects of ES during the palatal mucosa early healing process in Swiss mice. Methods: Ninety animals were divided into two groups: Control (C; n = 45), which received Sham ES applications, and Test (ES; n = 45), which received ES (100 μA; 9 kHz; 660 mVpp) once a day for 3 days. A full thickness wound was performed with a 1.5 mm diameter biopsy punch in the hard palate. Histologically, the following parameters were evaluated: palatal wound closure and epithelial and connective wound edge distance (EED and CED). Furthermore, IL-1β, IL-6, IL-10 TNF-α, and VEGF cytokine levels were evaluated by multiplex assay. The percentage of collagen fibers was assessed using the polarization method and the Smad proteins using the immunofluorescence method. Results: Palatal wound closure presented a significant reduction on day 5 in the ES group (p = 0.01). Additionally, both EED and CED were shorter for all time points in the ES group (p < 0.05), and the inflammatory markers IL-6, IL-10, TNF-α, and VEGF were reduced (p < 0.05). There were no differences in collagen fibers and phospho-Smad2 between the groups. Conclusion: ES had a positive effect on early palatal wound closure outcomes, as well as on inflammatory markers.-
Descrição: dc.descriptionPostgraduate Student Oral Biopathology Program São Paulo State University (UNESP) College of Dentistry, Periodontics Area-
Descrição: dc.descriptionSão Paulo State University (UNESP) Division of Periodontics Institute of Science and Technology-
Descrição: dc.descriptionUniversity of Campinas (UNICAMP) Department of Prosthodontics and Periodontics Division of Periodontics Piracicaba Dental School-
Descrição: dc.descriptionFEI – College of Industrial Engineering-
Descrição: dc.descriptionUniversity of Michigan School of Dentistry Department of Biologic and Materials Sciences & Prosthodontics-
Descrição: dc.descriptionPostgraduate Student Oral Biopathology Program São Paulo State University (UNESP) College of Dentistry, Periodontics Area-
Descrição: dc.descriptionSão Paulo State University (UNESP) Division of Periodontics Institute of Science and Technology-
Idioma: dc.languageen-
Relação: dc.relationArchives of Oral Biology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectElectrical stimulation-
Palavras-chave: dc.subjectGingival recession-
Palavras-chave: dc.subjectHard palate-
Palavras-chave: dc.subjectOral mucosa-
Palavras-chave: dc.subjectRe-epithelialization-
Palavras-chave: dc.subjectWound healing-
Título: dc.titleElectrical stimulation enhances early palatal wound healing in mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.