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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Universidade Estadual de Campinas (UNICAMP) | - |
Autor(es): dc.contributor | FEI – College of Industrial Engineering | - |
Autor(es): dc.contributor | School of Dentistry | - |
Autor(es): dc.creator | Ferreira, Camila Lopes [UNESP] | - |
Autor(es): dc.creator | Neves Jardini, Maria Aparecida [UNESP] | - |
Autor(es): dc.creator | Moretto Nunes, Camilla Magnoni [UNESP] | - |
Autor(es): dc.creator | Bernardo, Daniella Vicensotto [UNESP] | - |
Autor(es): dc.creator | Viana Casarin, Renato Corrêa | - |
Autor(es): dc.creator | dos Santos Gedraite, Estevão | - |
Autor(es): dc.creator | Mathias, Márcio Antônio | - |
Autor(es): dc.creator | Liu, Fei | - |
Autor(es): dc.creator | Mendonça, Gustavo | - |
Autor(es): dc.creator | Silveira Mendonça, Daniela Baccelli | - |
Autor(es): dc.creator | Santamaria, Mauro Pedrine [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:52:59Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:52:59Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-01-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1016/j.archoralbio.2020.105028 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/208284 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/208284 | - |
Descrição: dc.description | Background/objective: Electrical stimulation (ES) has been used to treat chronic wound and other clinical applications, showing favorable results in wound closure. It was hypothesized that ES can present a positive effect on oral mucosa healing. The aim of this study was to investigate the effects of ES during the palatal mucosa early healing process in Swiss mice. Methods: Ninety animals were divided into two groups: Control (C; n = 45), which received Sham ES applications, and Test (ES; n = 45), which received ES (100 μA; 9 kHz; 660 mVpp) once a day for 3 days. A full thickness wound was performed with a 1.5 mm diameter biopsy punch in the hard palate. Histologically, the following parameters were evaluated: palatal wound closure and epithelial and connective wound edge distance (EED and CED). Furthermore, IL-1β, IL-6, IL-10 TNF-α, and VEGF cytokine levels were evaluated by multiplex assay. The percentage of collagen fibers was assessed using the polarization method and the Smad proteins using the immunofluorescence method. Results: Palatal wound closure presented a significant reduction on day 5 in the ES group (p = 0.01). Additionally, both EED and CED were shorter for all time points in the ES group (p < 0.05), and the inflammatory markers IL-6, IL-10, TNF-α, and VEGF were reduced (p < 0.05). There were no differences in collagen fibers and phospho-Smad2 between the groups. Conclusion: ES had a positive effect on early palatal wound closure outcomes, as well as on inflammatory markers. | - |
Descrição: dc.description | Postgraduate Student Oral Biopathology Program São Paulo State University (UNESP) College of Dentistry, Periodontics Area | - |
Descrição: dc.description | São Paulo State University (UNESP) Division of Periodontics Institute of Science and Technology | - |
Descrição: dc.description | University of Campinas (UNICAMP) Department of Prosthodontics and Periodontics Division of Periodontics Piracicaba Dental School | - |
Descrição: dc.description | FEI – College of Industrial Engineering | - |
Descrição: dc.description | University of Michigan School of Dentistry Department of Biologic and Materials Sciences & Prosthodontics | - |
Descrição: dc.description | Postgraduate Student Oral Biopathology Program São Paulo State University (UNESP) College of Dentistry, Periodontics Area | - |
Descrição: dc.description | São Paulo State University (UNESP) Division of Periodontics Institute of Science and Technology | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Archives of Oral Biology | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Electrical stimulation | - |
Palavras-chave: dc.subject | Gingival recession | - |
Palavras-chave: dc.subject | Hard palate | - |
Palavras-chave: dc.subject | Oral mucosa | - |
Palavras-chave: dc.subject | Re-epithelialization | - |
Palavras-chave: dc.subject | Wound healing | - |
Título: dc.title | Electrical stimulation enhances early palatal wound healing in mice | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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