Atenção: Todas as denúncias são sigilosas e sua identidade será preservada.
Os campos nome e e-mail são de preenchimento opcional
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Private practice. Director of the Pro-clinic Nucleus of Orofacial Harmonization | - |
Autor(es): dc.creator | Matheus, Henrique R [UNESP] | - |
Autor(es): dc.creator | Ervolino, Edilson [UNESP] | - |
Autor(es): dc.creator | Gusman, David Jonathan Rodrigues [UNESP] | - |
Autor(es): dc.creator | Alves, Breno Edson Sendão [UNESP] | - |
Autor(es): dc.creator | Fiorin, Luiz Guilherme [UNESP] | - |
Autor(es): dc.creator | Pereira, Priscilla Aparecida | - |
Autor(es): dc.creator | de Almeida, Juliano Milanezi [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:52:51Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:52:51Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2019-12-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1002/JPER.20-0613 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/208252 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/208252 | - |
Descrição: dc.description | Background: This study is designed to evaluate the potential of different formulations of hyaluronic acid (HA) to improve new bone formation in critical-size calvaria defect (CSD) when combined with a deproteinized bovine graft (DBG) material. Methods: Thirty male rats were used. A 5-mm-diameter CSD was created and three experimental groups (n = 10) were randomly assigned based on the treatments performed. Group DBG: CSD filled with a DBG; group DBG/LV: CSD filled by the combination of DBG and HA in a low-viscosity crosslinking agent; group DBG/HV: CSD filled by the combination of DBG and HA in a high-viscosity crosslinking agent. Animals were euthanized 30 days postoperatively. Histological, histometric (percentage of newly formed bone [PNFB], percentage of remaining graft particles, histochemical, and immunohistochemical (bone morphogenetic protein 2/4 [BMP2/4], osteocalcin [OCN], and tartrate-resistant acid phosphatase [TRAP]) analyses were performed. Results: The highest PNFB was observed in DBG/HV when compared with the other groups (P ≤0.05). DBG/LV and DBG/HV presented almost no inflammatory cells. In contrast, inflammation was observed in group DBG. Extensive resorption of graft particles was observed in group DBG, which was not present in DBG/LV and DBG/HV as confirmed by the larger size of the particles (P ≤0.05). BMP2/4 and OCN immunolabeling were higher in DBG/HV when compared with group DBG (P ≤0.05). Increased number of TRAP-positive cells was observed in DBG/LV and DBG/HV (P ≤0.05). Lower percentage of mature collagen fibers was observed in DBG/HV (P ≤0.05). Conclusion: The combination of HA in a high-viscosity crosslinking agent with DBG improves the bone repair process and increases the amount of newly formed bone towards CSDs in rat calvaria. | - |
Descrição: dc.description | Department of Diagnosis and Surgery‒Periodontics Division School of Dentistry São Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Basic Science School of Dentistry São Paulo State University (UNESP) | - |
Descrição: dc.description | Private practice. Director of the Pro-clinic Nucleus of Orofacial Harmonization | - |
Descrição: dc.description | Department of Diagnosis and Surgery‒Periodontics Division School of Dentistry São Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Basic Science School of Dentistry São Paulo State University (UNESP) | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Journal of Periodontology | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | animal experimentation | - |
Palavras-chave: dc.subject | biomarkers | - |
Palavras-chave: dc.subject | bone | - |
Palavras-chave: dc.subject | bone regeneration | - |
Palavras-chave: dc.subject | bone transplantation | - |
Título: dc.title | Association of hyaluronic acid with a deproteinized bovine graft improves bone repair and increases bone formation in critical-size bone defects | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: