A review of analytical methods for the determination of tibolone: Phar-macokinetics and pharmaceutical formulations analysis and application in doping control

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Alfenas-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorBangor University-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorÂngelo, Marilene Lopes-
Autor(es): dc.creatorMoreira, Fernanda de Lima-
Autor(es): dc.creatorSantos, Ana Laura Araújo-
Autor(es): dc.creatorSalgado, Hérida Regina Nunes [UNESP]-
Autor(es): dc.creatorde Araújo, Magali Benjamim-
Data de aceite: dc.date.accessioned2022-02-22T00:52:48Z-
Data de disponibilização: dc.date.available2022-02-22T00:52:48Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2174/1573412916666191025143214-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208236-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208236-
Descrição: dc.descriptionBackground: Tibolone is a synthetic steroid commercialized by Organon under the brand name Livial (Org OD14), which is used in hormone therapy for menopause management and treatment of postmenopausal osteoporosis. Tibolone is defined as a selective tissue estrogenic activity regulator (STEAR) demonstrating tissue-specific effects on several organs such as brain, breast, urogenital tract, endometrium, bone and cardiovascular system. Aims: This work aims to (1) present an overview of important published literature on existing methods for the analysis of tibolone and/or its metabolites in pharmaceutical formulations and biological fluids and (2) to conduct a critical comparison of the analytical methods used in doping control, pharmacoki-netics and pharmaceutical formulations analysis of tibolone and its metabolites. Results and Conclusion: The major analytical method described for the analysis of tibolone in pharmaceutical formulations is High Pressure Liquid Chromatography (HPLC) coupled with ultraviolet (UV) detection, while Liquid Chromatography (LC) or Gas Chromatography (GC) used in combination with Mass Spectrometry (MS) or tandem mass spectrometry (MS/MS) is employed for the analysis of tibolone and/or its metabolites in biological fluids.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionFaculty of Pharmaceutical Sciences Federal University of Alfenas, 700, Rua Gabriel Monteiro da Silva-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo-
Descrição: dc.descriptionSchool of Biological Sciences Bangor University, Deiniol Road-
Descrição: dc.descriptionFaculty of Pharmaceutical Sciences UNESP Campus Araraquara, Rodovia Araraquara Jaú, km 01-
Descrição: dc.descriptionFaculty of Pharmaceutical Sciences UNESP Campus Araraquara, Rodovia Araraquara Jaú, km 01-
Formato: dc.format31-39-
Idioma: dc.languageen-
Relação: dc.relationCurrent Pharmaceutical Analysis-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnalytical methods-
Palavras-chave: dc.subjectGC-MS-
Palavras-chave: dc.subjectHPLC-
Palavras-chave: dc.subjectLC-MS/MS-
Palavras-chave: dc.subjectTibolone-
Palavras-chave: dc.subjectUPLC-MS/MS-
Título: dc.titleA review of analytical methods for the determination of tibolone: Phar-macokinetics and pharmaceutical formulations analysis and application in doping control-
Aparece nas coleções:Repositório Institucional - Unesp

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