Atenção: Todas as denúncias são sigilosas e sua identidade será preservada.
Os campos nome e e-mail são de preenchimento opcional
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Universidade Federal de Goiás (UFG) | - |
Autor(es): dc.creator | do Nascimento, Patrícia Aleixa [UNESP] | - |
Autor(es): dc.creator | Kogawa, Ana Carolina [UNESP] | - |
Autor(es): dc.creator | Nunes Salgado, Hérida Regina [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:52:42Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:52:42Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2019-12-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1093/JAOACINT/QSAA068 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/208201 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/208201 | - |
Descrição: dc.description | Background: Vancomycin, an antimicrobial, has many microbiological methods in literature, but it was not found any that follows the green chemistry principles. Objective: The aim of this work was to develop and validate a new microbiological analytical method with a green view to determine the vancomycin potency in lyophilized powder using less quantity of diluents and culture medium, minimizing the costs and reducing the time of analysis. Methods: The objective will be achieved using the microbiological method by turbidimetry. Results: Water was used as the diluent to prepare the vancomycin solution. BHI broth as used as culture media for the growth of the S. aureus ATCC 25923. The method was linear in the range of 30, 39 and 50.7 mg/mL. It was selective, with vancomycin reference and sample absorbance values very similar. The precision of the method was proved at intraday (RSD 4.42 %), interday (RSD 3.56 %) and intermediate levels (RSD 2.03%). It was accurate with mean recovery of 100.71 % and robust when changes were performed in three parameters of the method and analyzed by the F-Test and t-Test. Conclusions: The method for evaluating the potency of vancomycin in pharmaceutical product was successfully developed and validated. Highlights: The method can be applied to routine quality control of vancomycin product as an alternative that contemplates the green analytical chemistry and the current pharmaceutical analyzes. | - |
Descrição: dc.description | Department of Pharmaceutics School of Pharmaceutical Sciences of Araraquara Univ Estadual Paulista-UNESP | - |
Descrição: dc.description | Laboratório de Controle de Qualidade Faculdade de Farmácia Universidade Federal de Goiás-UFG | - |
Descrição: dc.description | Department of Pharmaceutics School of Pharmaceutical Sciences of Araraquara Univ Estadual Paulista-UNESP | - |
Formato: dc.format | 1582-1587 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Journal of AOAC International | - |
???dc.source???: dc.source | Scopus | - |
Título: dc.title | Turbidimetric method: A new, ecological, and fast way to evaluate of vancomycin potency | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: