Evaluation of chemical restraint, isoflurane anesthesia and methadone or tramadol as preventive analgesia in spotted pacas (Cuniculus paca) subjected to laparoscopy

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Autor(es): dc.contributorUniversidade Federal de Viçosa (UFV)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorFederal Rural University of Rio de Janeiro (UFRRJ)-
Autor(es): dc.contributorUniversidade Federal de Sergipe (UFS)-
Autor(es): dc.creatorUscategui, Ricardo AR. [UNESP]-
Autor(es): dc.creatorBarros, Felipe FPC.-
Autor(es): dc.creatorAlmeida, Vívian T. [UNESP]-
Autor(es): dc.creatorKawanami, Aline E. [UNESP]-
Autor(es): dc.creatorFeliciano, Marcus AR.-
Autor(es): dc.creatorVicente, Wilter RR. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:52:42Z-
Data de disponibilização: dc.date.available2022-02-22T00:52:42Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.vaa.2020.09.001-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208198-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208198-
Descrição: dc.descriptionObjective: To evaluate the efficacy and cardiopulmonary effects of ketamine–midazolam for chemical restraint, isoflurane anesthesia and tramadol or methadone as preventive analgesia in spotted pacas subjected to laparoscopy. Study design: Prospective placebo-controlled blinded trial. Animals: A total of eight captive female Cuniculus paca weighing 9.3 ± 0.9 kg. Methods: Animals were anesthetized on three occasions with 15 day intervals. Manually restrained animals were administered midazolam (0.5 mg kg–1) and ketamine (25 mg kg–1) intramuscularly. Anesthesia was induced and maintained with isoflurane 30 minutes later. Tramadol (5 mg kg–1), methadone (0.5 mg kg–1) or saline (0.05 mL kg–1) were administered intramuscularly 15 minutes prior to laparoscopy. Heart rate (HR), respiratory rate, mean arterial pressure (MAP), peripheral oxygen saturation (SpO2), end-tidal CO2 partial pressure (PE′CO2), end-tidal concentration of isoflurane (FE′Iso), pH, PaO2, PaCO2, bicarbonate (HCO3−), anion gap (AG) and base excess (BE) were monitored after chemical restraint, anesthesia induction and at different laparoscopy stages. Postoperative pain was assessed by visual analog scale (VAS) for 24 hours. Variables were compared using ANOVA or Friedman test (p < 0.05). Results: Chemical restraint was effective in 92% of animals. Isoflurane anesthesia was effective; however, HR, MAP, pH and AG decreased, whereas PE′CO2, PaO2, PaCO2, HCO3− and BE increased. MAP was stable with tramadol and methadone treatments; HR, FE′Iso and postoperative VAS decreased. VAS was lower for a longer time with methadone treatment; SpO2 and AG decreased, whereas PE′CO2, PaCO2 and HCO3− increased. Conclusions and clinical relevance: Ketamine–midazolam provided satisfactory restraint. Isoflurane anesthesia for laparoscopy was effective but resulted in hypotension and respiratory acidosis. Tramadol and methadone reduced isoflurane requirements, provided postoperative analgesia and caused hypercapnia, with methadone causing severe respiratory depression. Thus, the anesthetic protocol is adequate for laparoscopy in Cuniculus paca; however, methadone should be avoided.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionInstitute of Agrarian Sciences Federal University of Jequithonha and Mucury Valleys (UFVJM)-
Descrição: dc.descriptionDepartment of Veterinary Pathobiology and Theriogenology São Paulo State University (Unesp) “Julio de Mesquita Filho”-
Descrição: dc.descriptionDepartment of Medicine and Veterinary Surgery Federal Rural University of Rio de Janeiro (UFRRJ)-
Descrição: dc.descriptionDepartment of Large Animal Clinic Federal University of Santa Maria (UFSM)-
Descrição: dc.descriptionDepartment of Veterinary Pathobiology and Theriogenology São Paulo State University (Unesp) “Julio de Mesquita Filho”-
Descrição: dc.descriptionCAPES: 14835126-
Descrição: dc.descriptionFAPESP: FAPESP 2012/00724-6-
Formato: dc.format82-91-
Idioma: dc.languageen-
Relação: dc.relationVeterinary Anaesthesia and Analgesia-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectisoflurane-
Palavras-chave: dc.subjectketamine-
Palavras-chave: dc.subjectmethadone-
Palavras-chave: dc.subjectmidazolam-
Palavras-chave: dc.subjectrodents-
Palavras-chave: dc.subjecttramadol-
Título: dc.titleEvaluation of chemical restraint, isoflurane anesthesia and methadone or tramadol as preventive analgesia in spotted pacas (Cuniculus paca) subjected to laparoscopy-
Tipo de arquivo: dc.typelivro digital-
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