Polymorphisms in TLR4 Gene Associated With Somatic Cell Score in Water Buffaloes (Bubalus bubalis)

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Guelph-
Autor(es): dc.contributorUniversidad Francisco de Paula Santander-
Autor(es): dc.contributorUniversity of Maryland-
Autor(es): dc.contributorUniversidade Federal da Bahia (UFBA)-
Autor(es): dc.creatorRoldan-Montes, Valentina [UNESP]-
Autor(es): dc.creatorCardoso, Diercles Francisco [UNESP]-
Autor(es): dc.creatorHurtado-Lugo, Naudin Alejandro-
Autor(es): dc.creatordo Nascimento, André Vieira [UNESP]-
Autor(es): dc.creatorSantos, Daniel Jordan de Abreu [UNESP]-
Autor(es): dc.creatorScalez, Daiane Cristina Becker [UNESP]-
Autor(es): dc.creatorde Freitas, Ana Cláudia [UNESP]-
Autor(es): dc.creatorHerrera, Ana Cristina [UNESP]-
Autor(es): dc.creatorAlbuquerque, Lucia Galvão [UNESP]-
Autor(es): dc.creatorde Camargo, Gregório Miguel Ferreira-
Autor(es): dc.creatorTonhati, Humberto [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:52:33Z-
Data de disponibilização: dc.date.available2022-02-22T00:52:33Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-11-04-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fvets.2020.568249-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208152-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208152-
Descrição: dc.descriptionConsidering the importance of the diseases affecting the productive performance of animals in the dairy industry worldwide, it is necessary to implement tools that help to control and limit the occurrence of such diseases. As the increased somatic cell counts (SCC) are a direct expression of the inflammatory process, they are candidates to become the usual parameter for assessing udder health regarding milk quality and for monitoring mastitis incidences. Toll-Like Receptors are membrane proteins that play a key role in immunity, recognizing pathogens and, subsequently, activating immune responses. The present study was conducted to identify single nucleotide polymorphisms in the TLR4 gene of buffaloes and to analyze its associations with somatic cell counts. DNA samples of 120 Murrah buffaloes were used. The whole coding region of the TLR4 gene was amplified by polymerase chain reaction reactions and sequenced for polymorphism scanning. A total of 13 polymorphisms were identified for the sequenced regions of the TLR4, most of which are in the coding region. The association with the somatic cell score was highly significant (p < 0.001) for all identified polymorphisms of TLR4 gene (g.54621T>A, g.54429G>T, g.54407T>A, g.46616C>A, g.46613T>G, g.46612A>G, g.46611C>A, g.46609T>G, g.46541C>G, g.46526C>A, g.46516T>C, g.46376C>T, g.46372T>C). Therefore, it is suggested that the markers of the TLR4 gene can be used as molecular markers for mastitis resistance in buffaloes, due to their association with somatic cell counts.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Animal Science School of Agricultural and Veterinarian Science São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Animal Biosciences Centre for Genetic Improvement of Livestock University of Guelph-
Descrição: dc.descriptionFacultad de Ciências Agrárias Universidad Francisco de Paula Santander-
Descrição: dc.descriptionDepartment of Animal and Avian Sciences University of Maryland-
Descrição: dc.descriptionEscola de Medicina Veterinária e Zootecnia Universidade Federal da Bahia-
Descrição: dc.descriptionDepartment of Animal Science School of Agricultural and Veterinarian Science São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Veterinary Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectmastitis-
Palavras-chave: dc.subjectmilk yield-
Palavras-chave: dc.subjectmolecular marker analysis-
Palavras-chave: dc.subjectSNP-
Palavras-chave: dc.subjectstop codon-
Palavras-chave: dc.subjectudder health-
Título: dc.titlePolymorphisms in TLR4 Gene Associated With Somatic Cell Score in Water Buffaloes (Bubalus bubalis)-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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