Systemic cytokine profiles of CD4+ t lymphocytes correlate with clinical features and functional status in stable COPD

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorFederal University of Rio de Janeiro-
Autor(es): dc.creatorUzeloto, Juliana Souza [UNESP]-
Autor(es): dc.creatorde Toledo-Arruda, Alessandra Choqueta-
Autor(es): dc.creatorSilva, Bruna Spolador de Alencar [UNESP]-
Autor(es): dc.creatorGolim, Marjorie de Assis [UNESP]-
Autor(es): dc.creatorBraz, Aline Márcia Marques [UNESP]-
Autor(es): dc.creatorGrigoletto, Fabiano Francisco de Lima Isis [UNESP]-
Autor(es): dc.creatorRamos, Ercy Mara Cipulo [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:52:31Z-
Data de disponibilização: dc.date.available2022-02-22T00:52:31Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2147/COPD.S268955-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208141-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208141-
Descrição: dc.descriptionAims: To evaluate the expressions of intracellular cytokines in CD4+ T lymphocytes and to investigate the correlation between biomarker expressions and clinical and functional characteristics of stable COPD patients. Patients and Methods: Peripheral blood was collected from 36 COPD patients, and the expression of cytokines (IL-8, IL-13, IL-17, IL-6, IL-2, IL-10, and TNF-α) in T lymphocytes CD4 + was investigated. In addition, lung function, dyspnea symptoms, quality of life, vital signs, body composition, level of physical activity, peripheral muscle strength, and functional capacity were assessed. Results: Individuals with greater bronchial obstruction present a higher proportion of CD4 + IL-2 + lymphocytes compared to individuals with less severe bronchial obstruction. We found a positive correlation between the expression of the cytokines IL-13, IL-17, IL-6, IL-2, IL-10, and TNF-α in CD4+ T lymphocytes. In addition, we found a positive correlation between CD4+ IL-10+ T lymphocytes and lower limb muscle strength and a negative correlation between CD4+ IL-8+ T lymphocytes and peripheral oxygen saturation and steps per day. Conclusion: Systemic CD4+IL-2+, IL-8+, and IL-10+ T lymphocytes presented a correlation with clinical characteristics and functional status in stable COPD.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSão Paulo State University (UNESP) Faculty of Science and Technology Department of Physiotherapy Postgraduate Program in Physiotherapy-
Descrição: dc.descriptionDepartment of Physiotherapy Federal University of Rio de Janeiro-
Descrição: dc.descriptionSão Paulo State University (UNESP) Botucatu Medical School Postgraduate Program in Research & Development: Medical Biotechnology Blood Center Flow Cytometry Laboratory-
Descrição: dc.descriptionSão Paulo State University (UNESP) Faculty of Science and Technology Department of Physiotherapy Postgraduate Program in Physiotherapy-
Descrição: dc.descriptionSão Paulo State University (UNESP) Botucatu Medical School Postgraduate Program in Research & Development: Medical Biotechnology Blood Center Flow Cytometry Laboratory-
Descrição: dc.descriptionFAPESP: 2017/10145-7-
Descrição: dc.descriptionFAPESP: 2018/ 04870-3-
Formato: dc.format2931-2940-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of COPD-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectChronic obstructive pulmonary disease-
Palavras-chave: dc.subjectFlow cytometry-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectPhenotype-
Título: dc.titleSystemic cytokine profiles of CD4+ t lymphocytes correlate with clinical features and functional status in stable COPD-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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