Atenção: Todas as denúncias são sigilosas e sua identidade será preservada.
Os campos nome e e-mail são de preenchimento opcional
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Federal University of Rio de Janeiro | - |
Autor(es): dc.creator | Uzeloto, Juliana Souza [UNESP] | - |
Autor(es): dc.creator | de Toledo-Arruda, Alessandra Choqueta | - |
Autor(es): dc.creator | Silva, Bruna Spolador de Alencar [UNESP] | - |
Autor(es): dc.creator | Golim, Marjorie de Assis [UNESP] | - |
Autor(es): dc.creator | Braz, Aline Márcia Marques [UNESP] | - |
Autor(es): dc.creator | Grigoletto, Fabiano Francisco de Lima Isis [UNESP] | - |
Autor(es): dc.creator | Ramos, Ercy Mara Cipulo [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:52:31Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:52:31Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2019-12-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.2147/COPD.S268955 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/208141 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/208141 | - |
Descrição: dc.description | Aims: To evaluate the expressions of intracellular cytokines in CD4+ T lymphocytes and to investigate the correlation between biomarker expressions and clinical and functional characteristics of stable COPD patients. Patients and Methods: Peripheral blood was collected from 36 COPD patients, and the expression of cytokines (IL-8, IL-13, IL-17, IL-6, IL-2, IL-10, and TNF-α) in T lymphocytes CD4 + was investigated. In addition, lung function, dyspnea symptoms, quality of life, vital signs, body composition, level of physical activity, peripheral muscle strength, and functional capacity were assessed. Results: Individuals with greater bronchial obstruction present a higher proportion of CD4 + IL-2 + lymphocytes compared to individuals with less severe bronchial obstruction. We found a positive correlation between the expression of the cytokines IL-13, IL-17, IL-6, IL-2, IL-10, and TNF-α in CD4+ T lymphocytes. In addition, we found a positive correlation between CD4+ IL-10+ T lymphocytes and lower limb muscle strength and a negative correlation between CD4+ IL-8+ T lymphocytes and peripheral oxygen saturation and steps per day. Conclusion: Systemic CD4+IL-2+, IL-8+, and IL-10+ T lymphocytes presented a correlation with clinical characteristics and functional status in stable COPD. | - |
Descrição: dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
Descrição: dc.description | São Paulo State University (UNESP) Faculty of Science and Technology Department of Physiotherapy Postgraduate Program in Physiotherapy | - |
Descrição: dc.description | Department of Physiotherapy Federal University of Rio de Janeiro | - |
Descrição: dc.description | São Paulo State University (UNESP) Botucatu Medical School Postgraduate Program in Research & Development: Medical Biotechnology Blood Center Flow Cytometry Laboratory | - |
Descrição: dc.description | São Paulo State University (UNESP) Faculty of Science and Technology Department of Physiotherapy Postgraduate Program in Physiotherapy | - |
Descrição: dc.description | São Paulo State University (UNESP) Botucatu Medical School Postgraduate Program in Research & Development: Medical Biotechnology Blood Center Flow Cytometry Laboratory | - |
Descrição: dc.description | FAPESP: 2017/10145-7 | - |
Descrição: dc.description | FAPESP: 2018/ 04870-3 | - |
Formato: dc.format | 2931-2940 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | International Journal of COPD | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Chronic obstructive pulmonary disease | - |
Palavras-chave: dc.subject | Flow cytometry | - |
Palavras-chave: dc.subject | Inflammation | - |
Palavras-chave: dc.subject | Phenotype | - |
Título: dc.title | Systemic cytokine profiles of CD4+ t lymphocytes correlate with clinical features and functional status in stable COPD | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: