Identification of potential molecular pathways involved in prostate carcinogenesis in offspring exposed to maternal malnutrition

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorAlcantara Santos, Sérgio Alexandre [UNESP]-
Autor(es): dc.creatorLima Camargo, Ana Carolina [UNESP]-
Autor(es): dc.creatorConstantino, Flávia Bessi [UNESP]-
Autor(es): dc.creatorColombelli, Ketlin Thassiani [UNESP]-
Autor(es): dc.creatorFrediani Portela, Luiz Marcos [UNESP]-
Autor(es): dc.creatorFioretto, Matheus Naia [UNESP]-
Autor(es): dc.creatorSouza Vieira, José Cavalcante [UNESP]-
Autor(es): dc.creatorPadilha, Pedro Magalhães [UNESP]-
Autor(es): dc.creatorde Oliveira, Mateus Betta [UNESP]-
Autor(es): dc.creatorFelisbino, Sergio Luis [UNESP]-
Autor(es): dc.creatorCarvalho, Robson Francisco [UNESP]-
Autor(es): dc.creatorJustulin, Luis Antonio [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:52:30Z-
Data de disponibilização: dc.date.available2022-02-22T00:52:30Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.18632/aging.104093-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208132-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208132-
Descrição: dc.descriptionThe developmental origins of health and disease concept links adult diseases with early-life exposure to inappropriate environmental conditions. Intrauterine and postnatal malnutrition may lead to an increased incidence of type 2 diabetes, obesity, and cardiovascular diseases. Maternal malnutrition (MM) has also been associated with prostate carcinogenesis. However, the molecular mechanisms associated with this condition remain poorly understood. Using a proteomic analysis, we demonstrated that MM changed the levels of proteins associated with growth factors, estrogen signaling, detoxification, and energy metabolism in the prostate of both young and old rats. These animals also showed increased levels of molecular markers of endoplasmic reticulum function and histones. We further performed an in silico analysis that identified commonly deregulated proteins in the ventral prostate of old rats submitted to MM with a mouse model and patients with prostate cancer. In conclusion, our results demonstrated that estrogenic signaling pathways, endoplasmic reticulum functions, energy metabolism, and molecular sensors of protein folding and Ca2+ homeostasis, besides histone, and RAS-GTPase family appear to be involved in this process. Knowledge of these factors may raise discussions regarding the role of maternal dietary intervention as a public policy for the lifelong prevention of chronic diseases.-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Biosciences Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Biosciences Sao Paulo State University (UNESP)-
Formato: dc.format19954-19978-
Idioma: dc.languageen-
Relação: dc.relationAging-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDOHaD-
Palavras-chave: dc.subjectmass spectrometr-
Palavras-chave: dc.subjectmaternal exposure to low protein diet-
Palavras-chave: dc.subjectprostate diseases-
Título: dc.titleIdentification of potential molecular pathways involved in prostate carcinogenesis in offspring exposed to maternal malnutrition-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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