Dorsal hippocampus plays a causal role in context-induced reinstatement of alcohol-seeking in rats

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.creatorFelipe, Jaqueline Moreira-
Autor(es): dc.creatorPalombo, Paola-
Autor(es): dc.creatorBianchi, Paula Cristina-
Autor(es): dc.creatorZaniboni, Caroline Riberti-
Autor(es): dc.creatorAnésio, Augusto-
Autor(es): dc.creatorYokoyama, Thais Suemi-
Autor(es): dc.creatorEngi, Sheila Antonagi-
Autor(es): dc.creatorCarneiro-de-Oliveira, Paulo Eduardo-
Autor(es): dc.creatorPlaneta, Cleopatra da Silva [UNESP]-
Autor(es): dc.creatorLeão, Rodrigo Molini-
Autor(es): dc.creatorCruz, Fábio Cardoso-
Data de aceite: dc.date.accessioned2022-02-22T00:52:27Z-
Data de disponibilização: dc.date.available2022-02-22T00:52:27Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bbr.2020.112978-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/208115-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/208115-
Descrição: dc.descriptionDrug addiction is a chronic mental disorder characterized by frequent relapses. Contextual cues associated with drug use to play a critical causal role in drug-seeking behavior. The hippocampus has been implicated in encoding drug associative memories. Here we examine whether the dorsal hippocampus mediates context-induced reinstatement of alcohol-seeking. Male Long-Evans rats were trained to self-administer alcohol in Context A. Alcohol self-administration was extinguished in a distinct context (Context B). On the test day, animals were re-exposed to the alcohol Context A or the extinction Context B. Next, to assess a causal role for the dorsal hippocampus in context-induced alcohol-seeking, on the test day, we injected cobalt chloride (CoCl2; a nonselective synapse inhibitor) or vehicle into the dorsal hippocampus, and 15 min later, rats were tested by re-exposing them to the drug-associated context. The re-exposure to the alcohol-associated Context A reinstated alcohol seeking and increased Fos-positive cells in the dorsal hippocampus neurons (CA1, CA3, and Dentate Gyrus). Pharmacological inactivation with cobalt chloride of the dorsal hippocampus attenuated the reinstatement of alcohol-seeking. Our data suggest that the dorsal hippocampus may be involved in context-induced alcohol-seeking behavior.-
Descrição: dc.descriptionDepartment of Pharmacology Universidade Federal de São Paulo - UNIFESP-
Descrição: dc.descriptionPsychology Laboratory Psychology Department Universidade Federal de São Carlos - UFSCar-
Descrição: dc.descriptionLaboratory of Pharmacology São Paulo State University (Unesp) School of Pharmaceutical Sciences-
Descrição: dc.descriptionBiomedical Sciences Institute Universidade Federal de Uberlândia - UFU Uberlândia-
Descrição: dc.descriptionLaboratory of Pharmacology São Paulo State University (Unesp) School of Pharmaceutical Sciences-
Idioma: dc.languageen-
Relação: dc.relationBehavioural Brain Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAlcohol self-administration-
Palavras-chave: dc.subjectDrug environment-
Palavras-chave: dc.subjectExtinction-
Palavras-chave: dc.subjectReinstatement-
Título: dc.titleDorsal hippocampus plays a causal role in context-induced reinstatement of alcohol-seeking in rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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